General Information of DTT (ID: TTO3HT7)

DTT Name Transforming growth factor beta (TGFB) DTT Info
Gene Name TGFB

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Clinical Trial Drug(s)
Preclinical Drug(s)
11 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bintrafusp alfa DMB9LRJ Non-small-cell lung cancer 2C25 Phase 2 [1]
Fresolimumab DMFZ084 Brain cancer 2A00 Phase 2 [2]
LY2382770 DMH3YKJ Diabetic kidney disease GB61.Z Phase 2 [3]
M7824 DMJCULI Solid tumour/cancer 2A00-2F9Z Phase 2 [4]
NIS793 DM8LBYT Pancreatic ductal carcinoma 2C10.0 Phase 2 [4]
TEW-7197 DM2LBC3 Myeloproliferative neoplasm 2A20 Phase 2 [4]
ACE-011 DMJ36YH Anemia 3A00-3A9Z Phase 1 [5]
AVID200 DMZ39T6 Solid tumour/cancer 2A00-2F9Z Phase 1 [6]
BCA101 DMM0VBU Solid tumour/cancer 2A00-2F9Z Phase 1 [7]
GS-1423 DMS25DL Solid tumour/cancer 2A00-2F9Z Phase 1 [8]
RG6440 DMVQXFH Aggressive cancer 2A00-2F9Z Phase 1 [9]
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⏷ Show the Full List of 11 Clinical Trial Drug(s)
1 Preclinical Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
SHP-627 DMHAONP Cardiac arrest MC82 Preclinical [10]
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Molecule Interaction Atlas

References

1 Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF- and PD-L1, in Second-Line Treatment of Patients With NSCLC: Results From an Expansion Cohort of a Phase 1 Trial. J Thorac Oncol. 2020 Jul;15(7):1210-1222.
2 Focal Irradiation and Systemic TGF Blockade in Metastatic Breast Cancer. Clin Cancer Res. 2018 Jun 1;24(11):2493-2504.
3 A phase I dose-escalation study to a predefined dose of a transforming growth factor-1 monoclonal antibody (TM1) in patients with metastatic cancer. Int J Oncol. 2014 Dec;45(6):2221-31.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Clinical pipeline report, company report or official report of Acceleron Pharma (2011).
6 TGF signaling underlies hematopoietic dysfunction and bone marrow failure in Shwachman-Diamond Syndrome. J Clin Invest. 2019 Jun 18;129(9):3821-3826.
7 ClinicalTrials.gov (NCT04429542) Study of Safety and Tolerability of BCA101 Alone and in Combination With Pembrolizumab in Patients With EGFR-driven Advanced Solid Tumors. U.S. National Institutes of Health.
8 Clinical pipeline report, company report or official report of Agenus.
9 Clinical pipeline report, company report or official report of Roche
10 Drugs and Targets in Fibrosis. Front Pharmacol. 2017 Nov 23;8:855.