General Information of DTT (ID: TTO9X1H)

DTT Name 5-HT 7 receptor (HTR7) DTT Info
Gene Name HTR7

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Patented Agent(s)
Investigative Drug(s)
4 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
AVN-101 DMOGFNI Cognitive impairment 6D71 Phase 2 [1]
JNJ-18038683 DMV1T59 Major depressive disorder 6A70.3 Phase 2 [2]
RP5063 DMKUE8O Schizophrenia 6A20 Phase 2 [3]
ATI-9242 DM6GKMU Schizophrenia 6A20 Phase 1 [4]
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4 Patented Agent(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
4-oxadiazole derivative 1 DMWFHKR N. A. N. A. Patented [5]
Carbamide derivative 2 DMW5GI3 N. A. N. A. Patented [5]
PMID30124346-Compound-13TABLE4 DMHTJVA Attention deficit hyperactivity disorder 6A05.Z Patented [6]
PMID30124346-Compound-34TABLE4 DM2G3VE Attention deficit hyperactivity disorder 6A05.Z Patented [6]
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1 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
SB-269970 DM8WTGA Sleep-wake disorder 7A00-7B2Z Terminated [7]
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63 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
(+/-)-nantenine DM0L3GE Discovery agent N.A. Investigative [8]
(2-biphenyl-3-yl-ethyl)-dimethyl-amine DMTW0GD Discovery agent N.A. Investigative [9]
(R)-8-phenyl-N,N-dipropylchroman-3-amine DMCY76E Discovery agent N.A. Investigative [10]
1-(2-Methoxy-phenyl)-piperazine DM3M4RA Discovery agent N.A. Investigative [11]
1-(3-(pentafluorosulfanyl)phenyl)propan-2-amine DMX5N3V Discovery agent N.A. Investigative [12]
1-naphthylpiperazine DM6BIWK Discovery agent N.A. Investigative [13]
2-(1-o-tolyl-1H-pyrrol-3-yl)ethanamine DMY35HG Discovery agent N.A. Investigative [9]
2-(2'-methyl-biphenyl-3-yl)-ethylamine DM7HN4Z Discovery agent N.A. Investigative [9]
2-(2-Bromophenoxy)-N,N-dimethylethanamine DMHBE0X Discovery agent N.A. Investigative [10]
2-(2-Bromophenylthio)-N,N-dimethylethanamine DMHJMUX Discovery agent N.A. Investigative [10]
2-(Biphenyl-2-yloxy)-N,N-dimethylethanamine DM0C5O3 Discovery agent N.A. Investigative [10]
2-(Biphenyl-2-ylthio)-N,N-dimethylethanamine DM9XZSC Discovery agent N.A. Investigative [10]
2-bromo-LSD DMOYCWU Discovery agent N.A. Investigative [14]
2-[1-(2-Chloro-phenyl)-1H-pyrrol-2-yl]-ethylamine DMSW89U Discovery agent N.A. Investigative [15]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G Discovery agent N.A. Investigative [16]
5,6-dichloro-3,4-dihydroquinazolin-2-amine DMN1S35 Discovery agent N.A. Investigative [17]
5-chloro-3,4-dihydroquinazolin-2-amine DMKEFJ0 Discovery agent N.A. Investigative [17]
5-chloro-4-ethyl-3,4-dihydroquinazolin-2-amine DMGDTNI Discovery agent N.A. Investigative [17]
5-chloro-4-methyl-3,4-dihydroquinazolin-2-amine DM7FZU2 Discovery agent N.A. Investigative [17]
5-CT DM260KD Discovery agent N.A. Investigative [14]
8-methoxy-4-methyl-3,4-dihydroquinazolin-2-amine DMK6U2V Discovery agent N.A. Investigative [17]
AS-19 DMASE5O Discovery agent N.A. Investigative [18]
bufotenine DMD1SY9 Discovery agent N.A. Investigative [14]
cyamemazine DMZ6YPV Discovery agent N.A. Investigative [19]
dihydroergocryptine DMDW2NL Discovery agent N.A. Investigative [14]
dipropyl-5-CT DM9VKXC Discovery agent N.A. Investigative [20]
Disulergine DM6TVAX Discovery agent N.A. Investigative [21]
DM-1451 DMM0VDK Discovery agent N.A. Investigative [22]
DR-4004 DMW8ORN Discovery agent N.A. Investigative [21]
E55888 DM0O8KR Discovery agent N.A. Investigative [23]
EDMT DMS3AXK Discovery agent N.A. Investigative [24]
Elaidoylamide DMP8VDT Discovery agent N.A. Investigative [25]
FALCARINDIOL DMLOV18 Discovery agent N.A. Investigative [26]
fluperlapine DM9KIPU Discovery agent N.A. Investigative [27]
IMPERATORIN DMVLW6R Discovery agent N.A. Investigative [26]
LP-12 DM8ZR17 Discovery agent N.A. Investigative [28]
LP-211 DMKDGLA Discovery agent N.A. Investigative [29]
LP-44 DM0C3SF Discovery agent N.A. Investigative [28]
m-chlorophenylpiperazine DMM1J2D Discovery agent N.A. Investigative [11]
MESULERGINE DMKGWAH Discovery agent N.A. Investigative [30]
METHIOTHEPIN DMMC0I7 Discovery agent N.A. Investigative [31]
MPDT DMYX31S Discovery agent N.A. Investigative [24]
N,N-dimethyl-2-(2'-methylbiphenyl-3-yl)ethanamine DM1DZEL Discovery agent N.A. Investigative [10]
N-methyl-Pip-F-homoF-vinyl sulfonyl phenyl (N-methyl-Pip-F-hF-VS phi) DMDAN0K Discovery agent N.A. Investigative [32]
OPC 4392 DMQOJY2 Discovery agent N.A. Investigative [22]
P-hydroxyphenethyl trans-ferulate DMPS1Y2 Discovery agent N.A. Investigative [26]
pirenperone DM9T2G3 Discovery agent N.A. Investigative [20]
SB 269970-A DMFHUGC Discovery agent N.A. Investigative [32]
SB-258719 DMO01AG Discovery agent N.A. Investigative [21]
SB-258741 DM0HK6L Discovery agent N.A. Investigative [21]
SB-271046 DM5VJAF Discovery agent N.A. Investigative [33]
SB-656104 DMVOIL5 Discovery agent N.A. Investigative [21]
SEL-73 DMFKE6C Psychiatric disorder 6E8Z Investigative [34]
SEROTONIN DMOFCRY Discovery agent N.A. Investigative [35]
TFMPP DMAC8TP Discovery agent N.A. Investigative [11]
UCM-5600 DMOJ4TG Discovery agent N.A. Investigative [30]
WAY-208466 DM9K2LU Discovery agent N.A. Investigative [36]
WAY-466 DMMOH51 Discovery agent N.A. Investigative [37]
[125I]LSD DMP69QG Discovery agent N.A. Investigative [38]
[3H]5-CT DMEAHFZ Discovery agent N.A. Investigative [7]
[3H]5-HT DMYJXV7 Discovery agent N.A. Investigative [13]
[3H]LSD DM0YJHS Discovery agent N.A. Investigative [39]
[3H]spiperone DMWHEV8 Discovery agent N.A. Investigative [21]
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⏷ Show the Full List of 63 Investigative Drug(s)
Molecule Interaction Atlas

References

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2 Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity. Front Behav Neurosci. 2015 Jan 15;8:453.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Pharmacological characteristics of ATI-9242, a Novel Atypical Antipsychotic. FASEB J, April, 2010, 24(Meeting Abstract Supplement),773.12.
5 Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58.
6 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689.
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8 Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31.
9 Novel aminoethylbiphenyls as 5-HT7 receptor ligands. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3018-22.
10 SAR studies on new bis-aryls 5-HT7 ligands: Synthesis and molecular modeling. Bioorg Med Chem. 2010 Mar 1;18(5):1958-67.
11 Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype. J Biol Chem. 1993 Aug 25;268(24):18200-4.
12 The synthesis and biological activity of pentafluorosulfanyl analogs of fluoxetine, fenfluramine, and norfenfluramine. Bioorg Med Chem. 2007 Nov 1;15(21):6659-66.
13 Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. J Biol Chem. 1993 Nov 5;268(31):23422-6.
14 Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase. Mol Pharmacol. 1993 Aug;44(2):229-36.
15 Phenylpyrroles, a new chemolibrary virtual screening class of 5-HT7 receptor ligands. Bioorg Med Chem Lett. 2005 Aug 15;15(16):3753-7.
16 Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97.
17 Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61.
18 Discovery of aryl-biphenyl-2-ylmethylpiperazines as novel scaffolds for 5-HT(7) ligands and role of the aromatic substituents in binding to the target receptor. Bioorg Med Chem. 2013 May 1;21(9):2568-76.
19 Affinity of cyamemazine, an anxiolytic antipsychotic drug, for human recombinant dopamine vs. serotonin receptor subtypes. Biochem Pharmacol. 2003 Feb 1;65(3):435-40.
20 Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b). Br J Pharmacol. 1997 Sep;122(1):126-32.
21 Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). J Med Chem. 2003 Jul 3;46(14):2795-812.
22 Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes. Neuropsychopharmacology. 1999 Jun;20(6):612-27.
23 5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice. Pain. 2009 Feb;141(3):239-47.
24 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. J Med Chem. 2000 Mar 9;43(5):1011-8.
25 Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors. Biochem Pharmacol. 1999 Dec 1;58(11):1807-13.
26 Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis. J Nat Prod. 2006 Apr;69(4):536-41.
27 Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther. 1994 Mar;268(3):1403-10.
28 Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2. J Med Chem. 2007 Aug 23;50(17):4214-21.
29 Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor act... J Med Chem. 2008 Sep 25;51(18):5813-22.
30 Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity. J Med Chem. 2009 Apr 23;52(8):2384-92.
31 Novel quinazolinone derivatives as 5-HT7 receptor ligands. Bioorg Med Chem. 2008 Mar 1;16(5):2570-8.
32 5-HT7 receptors. Curr Drug Targets CNS Neurol Disord. 2004 Feb;3(1):81-90.
33 Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists. Bioorg Med Chem Lett. 2008 Jan 15;18(2):738-43.
34 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 12).
35 Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69.
36 Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists. Bioorg Med Chem. 2009 Jul 15;17(14):5153-63.
37 Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists. J Med Chem. 2005 Jan 27;48(2):353-6.
38 A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms. Neuron. 1993 Sep;11(3):449-58.
39 Human serotonin 5-HT7 receptor: cloning and pharmacological characterisation of two receptor variants. FEBS Lett. 1997 Aug 25;413(3):489-94.