Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTOJ9QL)

• DTT Name: Endoplasmic reticulum to nucleus signaling 1 (ERN1) DTT Info
• Gene Name: ERN1

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ORIN1001	DM27RXS	Metastatic breast cancer	2C6Y	Phase 1/2	[1]

11 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
879325-11-8	DMP04Z6	N. A.	N. A.	Patented	[2]
AC1LE05K	DMPOR3G	N. A.	N. A.	Patented	[3]
BB 0223767	DM2DT6L	N. A.	N. A.	Patented	[4]
T8361	DM86BDS	N. A.	N. A.	Patented	[4]
US8614253, 29-1	DMJKFVU	N. A.	N. A.	Patented	[5]
US8614253, 29-19	DMVI83P	N. A.	N. A.	Patented	[6]
US8614253, 32-4	DMRSP2M	N. A.	N. A.	Patented	[6]
US8614253, 32-5	DMSQODK	N. A.	N. A.	Patented	[4]
US9040714, 155	DMDELNU	N. A.	N. A.	Patented	[2]
US9040714, 7	DM53Z4I	N. A.	N. A.	Patented	[2]
US9241942, 32-12	DM8GW54	N. A.	N. A.	Patented	[6]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
APY29	DMCOMLS	Solid tumour/cancer	2A00-2F9Z	Investigative	[7]
PMID24749861C34	DMJNQE1	Discovery agent	N.A.	Investigative	[8]

References

• [1] Clinical pipeline report, company report or official report of Orinove.
• [2] IRE-1 inhibitors. US9040714.
• [3] IRE-1 inhibitors. US9693992.
• [4] IRE-1 inhibitors. US8614253.
• [5] IRE-1 inhibitors. US9241942.
• [6] IRE-1 inhibitors. US9493435.
• [7] Quercetin ameliorates HFD-induced NAFLD by promoting hepatic VLDL assembly and lipophagy via the IRE1a/XBP1s pathway. Food Chem Toxicol. 2018 Apr;114:52-60.
• [8] Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity. J Med Chem. 2014 May 22;57(10):4289-301.