Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTP835K)

DTT Name	ATP-binding cassette transporter C8 (ABCC8) DTT Info
Gene Name	ABCC8

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

6 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetohexamide	DMR6N7H	Diabetic complication	5A2Y	Approved	[1]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[2]
Gliclazide	DMN6QO5	Diabetic complication	5A2Y	Approved	[3]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[4]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[5]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[6]
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⏷ Show the Full List of 6 Approved Drug(s)

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NN-414	DMRJEXM	Type-1 diabetes	5A10	Phase 1	[7]
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2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HBR-985	DMKDBFL	Discovery agent	N.A.	Investigative	[8]
NS-11757	DM98VMZ	Atrial fibrillation	BC81.3	Investigative	[9]
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Molecule Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1	Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection.Diabetes.2005 Nov;54(11):3065-72.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3	Structural basis for the interference between nicorandil and sulfonylurea action. Diabetes. 2001 Oct;50(10):2253-9.
4	Mechanism of disopyramide-induced hypoglycaemia in a patient with Type 2 diabetes. Diabet Med. 2009 Jan;26(1):76-8.
5	Metformin/Repaglinide (PrandiMet) for type 2 diabetes. Med Lett Drugs Ther. 2009 Jun 1;51(1313):41-3.
6	Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. J Clin Invest. 2009 Jan;119(1):80-90.
7	Attenuation of hyperinsulinemia by NN414, a SUR1/Kir6.2 selective K-adenosine triphosphate channel opener, improves glucose tolerance and lipid profile in obese Zucker rats.Metabolism.2004 Apr;53(4):441-7.
8	Cardioselective K(ATP) channel blockers derived from a new series of m-anisamidoethylbenzenesulfonylthioureas. J Med Chem. 2001 Mar 29;44(7):1085-98.
9	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2944).