Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTQWAU1)

• DTT Name: GSK3A messenger RNA (GSK3A mRNA) DTT Info
• Gene Name: GSK3A

Molecule-Related Drug & Molecule List

10 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
aloisine A	DM5U1LN	Discovery agent	N.A.	Investigative	[1]
CHIR-98014	DMVEBT6	Discovery agent	N.A.	Investigative	[2]
indirubin deriv. 8a	DMYLVQF	Discovery agent	N.A.	Investigative	[3]
ISIS 116625	DMIJES1	Discovery agent	N.A.	Investigative	[4]
ISIS 116631	DM2X5RT	Discovery agent	N.A.	Investigative	[4]
ISIS 116632	DMW2Q4T	Discovery agent	N.A.	Investigative	[4]
ISIS 116648	DMUOB3S	Discovery agent	N.A.	Investigative	[4]
ISIS 116654	DMBJU2X	Discovery agent	N.A.	Investigative	[4]
ISIS 116670	DM9R51M	Discovery agent	N.A.	Investigative	[4]
LEUCETTAMINE B	DMFQEWM	Discovery agent	N.A.	Investigative	[5]

References

• [1] Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46(2):222-36.
• [2] Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95.
• [3] Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J Med Chem. 2004 Feb 12;47(4):935-46.
• [4] US patent application no. 6,316,259, Antisense inhibition of glycogen synthase kinase 3 alpha expression.
• [5] Synthesis and preliminary biological evaluation of new derivatives of the marine alkaloid leucettamine B as kinase inhibitors. Eur J Med Chem. 2010 Feb;45(2):805-10.