General Information of DTT (ID: TTR6K75)

DTT Name 5-HT 3B receptor (HTR3B) DTT Info
Gene Name HTR3B

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Investigative Drug(s)
1 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
BEMESETRON DMSPJX9 N. A. N. A. Discontinued in Phase 3 [1]
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15 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
(S)-zacopride DM6BON2 Discovery agent N.A. Investigative [2]
1-phenylbiguanide DMA4XGL Discovery agent N.A. Investigative [2]
2-(1H-Imidazol-4-ylmethyl)-4-phenyl-thiazole DMCG1HE Discovery agent N.A. Investigative [3]
2-(4-Benzyl-piperazin-1-yl)-benzothiazole DM1V7EF Discovery agent N.A. Investigative [4]
2-(4-Methyl-piperazin-1-yl)-quinoline DMB8OY6 Discovery agent N.A. Investigative [5]
2-methyl-5-HT DM1S5CB N. A. N. A. Investigative [6]
6-(4-Methyl-piperazin-1-yl)-phenanthridine DM1HAWR Discovery agent N.A. Investigative [5]
bilobalide DM09Z35 Discovery agent N.A. Investigative [7]
BRL-24682 DMSB4EW Discovery agent N.A. Investigative [8]
MESULERGINE DMKGWAH Discovery agent N.A. Investigative [9]
meta-chlorphenylbiguanide DMEA8GP Discovery agent N.A. Investigative [2]
QUIPAZINE DMPY6IG Discovery agent N.A. Investigative [5]
SEROTONIN DMOFCRY Discovery agent N.A. Investigative [5]
trichloroethanol DMNALMF Discovery agent N.A. Investigative [10]
[3H]granisetron DMB9VGW Discovery agent N.A. Investigative [2]
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⏷ Show the Full List of 15 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Zatosetron, a potent, selective, and long-acting 5HT3 receptor antagonist: synthesis and structure-activity relationships. J Med Chem. 1992 Jan 24;35(2):310-9.
2 Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors. Neuropharmacology. 2001 Aug;41(2):282-4.
3 Aromatic thiazole derivatives: structurally novel and selective serotonin-3 receptor antagonists. J Med Chem. 1990 Jan;33(1):13-6.
4 Synthesis of 2-piperazinylbenzothiazole and 2-piperazinylbenzoxazole derivatives with 5-HT3 antagonist and 5-HT4 agonist properties. J Med Chem. 1994 Apr 29;37(9):1320-5.
5 Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy ... J Med Chem. 1999 May 6;42(9):1556-75.
6 The 5-HT3B subunit is a major determinant of serotonin-receptor function. Nature. 1999 Jan 28;397(6717):359-63.
7 Ginkgolide B and bilobalide block the pore of the 5-HT eceptor at a location that overlaps the picrotoxin binding site. Neuropharmacology. 2011 Feb-Mar;60(2-3):488-95.
8 Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotoni... J Med Chem. 2003 Feb 27;46(5):702-15.
9 Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure. J Med Chem. 1997 Oct 24;40(22):3670-8.
10 Co-expression of the 5-HT(3B) subunit with the 5-HT(3A) receptor reduces alcohol sensitivity. Brain Res Mol Brain Res. 2005 Dec 14;142(2):146-50.