Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTRANFM)

• DTT Name: Orphan nuclear receptor NR1I3 (NR1I3) DTT Info
• Gene Name: NR1I3

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclizine	DMS7T13	Dizziness	MB48	Approved	[1]

5 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(5BETA)-PREGNANE-3,20-DIONE	DMVQ6RN	Discovery agent	N.A.	Investigative	[2]
androstanol	DMPXF5I	Discovery agent	N.A.	Investigative	[3]
androstenol	DM7RXQ6	Discovery agent	N.A.	Investigative	[3]
CITCO	DM0N634	Discovery agent	N.A.	Investigative	[4]
TCPOBOP	DMKVF5Q	Discovery agent	N.A.	Investigative	[5]

References

• [1] Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR). Drug Metab Rev. 2006;38(1-2):51-73.
• [2] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [3] Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. Nature. 1998 Oct 8;395(6702):612-5.
• [4] Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. J Biol Chem. 2003 May 9;278(19):17277-83.
• [5] The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction. J Biol Chem. 2004 May 7;279(19):19832-8.