Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTRGHB2)

• DTT Name: SARS-CoV papain-like proteinase (PL-PRO) DTT Info
• Gene Name: SARS-CoV rep

Molecule-Related Drug & Molecule List

3 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[1]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[2]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[2]

2 Investigative Agents Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GRL-0667	DML09OS	Severe acute respiratory syndrome (SARS)	1D65	Investigative	[3]
PMID20527968-compound-6577871	DMI30V7	Severe acute respiratory syndrome (SARS)	1D65	Investigative	[3]

References

• [1] Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat Rev Drug Discov. 2020 Mar;19(3):149-150.
• [2] Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus. Antiviral Res. 2015 Mar;115:9-16.
• [3] Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biologic... J Med Chem. 2010 Jul 8;53(13):4968-79.