Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTRHUKY)

• DTT Name: Hepatitis C virus Serine protease NS4A (HCV NS4A) DTT Info
• Gene Name: HCV NS4A

Molecule-Related Drug & Molecule List

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TG-2349	DMZ571Y	Hepatitis C virus infection	1E51.1	Phase 2	[1]
MK-6325	DMV8BI4	Hepatitis C virus infection	1E51.1	Phase 1	[2]
PHX-1766	DMERJ6V	Hepatitis C virus infection	1E51.1	Phase 1	[3]

2 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GS-9132	DMXB4T9	Hepatitis C virus infection	1E51.1	Discontinued in Phase 1/2	[1]
IDX-320	DMAYLS3	Hepatitis C virus infection	1E51.1	Discontinued in Phase 1/2	[4]

References

• [1] Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
• [2] Synthesis of bis-macrocyclic HCV protease inhibitor MK-6325 via intramolecular sp -sp Suzuki-Miyaura coupling and ring closing metathesis. Org Lett. 2015 Mar 20;17(6):1533-6.
• [3] Pharmacokinetics and antiviral activity of PHX1766, a novel HCV protease inhibitor, using an accelerated Phase I study design. Antivir Ther. 2012;17(2):365-75.
• [4] Rapid decline of viral RNA in chronic hepatitis C patients treated once daily with IDX320: a novel macrocyclic HCV protease inhibitor.Antivir Ther.2012;17(4):633-42.