Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTSUKYD)

• DTT Name: Virus RNA-dependent RNA polymerase (Viru RdRP) DTT Info
• Gene Name: Viru RdRP

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AT-527	DMARIQK	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[1]

7 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FdG	DMYXA7E	Discovery agent	N.A.	Investigative	[2]
Guanosine-5'-Triphosphate	DMV2OJX	Discovery agent	N.A.	Investigative	[3]
Pyrimidinyl acylthiourea	DM7T2VQ	Discovery agent	N.A.	Investigative	[2]
Pyrophosphate 2-	DMZQ75M	Discovery agent	N.A.	Investigative	[4]
T-1105	DMGPQ0Y	Discovery agent	N.A.	Investigative	[2]
T-1106	DMPA2E9	Virus infection	1A24-1D9Z	Investigative	[2]
Thiadiazolo[2,3-a]pyrimidine	DMKRG2C	Discovery agent	N.A.	Investigative	[2]

References

• [1] AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e02479-20.
• [2] Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106. Antimicrob Agents Chemother. 2009 Jan;53(1):202-9.
• [3] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [4] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.