Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTU5CIX)

DTT Name	Ryanodine receptor 1 (RYR1) DTT Info
Gene Name	RYR1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

2 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ARM036	DMNGQM0	Heart failure	BD10-BD13	Discontinued in Phase 2	[1]
CDP-1050	DM5BG4P	Heart failure	BD10-BD13	Discontinued in Phase 1	[1]
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12 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(O10eq)-Benzyloxycarbonyl-beta-alanylryanodine	DMPYK1T	Discovery agent	N.A.	Investigative	[2]
(O10eq)-beta-alanyl-anhydro-ryanodine	DMRSZGB	Discovery agent	N.A.	Investigative	[2]
(O10eq)-beta-alanylryanodine	DMVGARN	Discovery agent	N.A.	Investigative	[2]
(O10eq)-beta-guanidinopropionylryanodine	DMSV8XM	Discovery agent	N.A.	Investigative	[2]
(O10eq)-guanidino acetylryanodine	DM97W5T	Discovery agent	N.A.	Investigative	[2]
ANHYDRORYANIDINE	DMGRWA3	Discovery agent	N.A.	Investigative	[2]
Benzyloxycarbonyl-glycylryanodine	DMLJMOD	Discovery agent	N.A.	Investigative	[2]
Di-Benzyloxycarbonyl-guanidino acetylryanodine	DMAYSGI	Discovery agent	N.A.	Investigative	[2]
GLYCYLRYANODINE	DMTOCXZ	Discovery agent	N.A.	Investigative	[2]
N-methyl ryanodine-succinamidate	DMXGY4F	Discovery agent	N.A.	Investigative	[2]
Ruthenium red	DMOHTC6	Discovery agent	N.A.	Investigative	[3]
Ryanodine	DM2K6I8	Discovery agent	N.A.	Investigative	[4]
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⏷ Show the Full List of 12 Investigative Drug(s)

Molecule Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1	The Ryanodine Receptor Stabilizer S44121 / Arm036 Improves Peripheral and Respiratory Muscle Function in a Mouse Model of Heart Failure. Circulation. 2014; 130: A13726.
2	Amino- and guanidinoacylryanodines: basic ryanodine esters with enhanced affinity for the sarcoplasmic reticulum Ca(2+)-release channel. J Med Chem. 1993 May 14;36(10):1319-23.
3	Role of ryanodine receptor channels in Ca2+ oscillations of porcine tracheal smooth muscle. Am J Physiol. 1997 Apr;272(4 Pt 1):L659-64.
4	The contribution of inositol 1,4,5-trisphosphate and ryanodine receptors to agonist-induced Ca(2+) signaling of airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L347-61.