Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTUHP71)

• DTT Name: Tyrosine 3-monooxygenase (TH) DTT Info
• Gene Name: TH

Molecule-Related Drug & Molecule List

4 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Phenylalanine	DMQXI9F	Malnutrition	5B50-5B71	Approved	[1]
L-Tyrosine	DM9O8DT	Malnutrition	5B50-5B71	Approved	[2]
Metyrosine	DMBYCU0	Pheochromocytoma	5A75	Approved	[3]
Tetrahydrobiopterin	DMINZ4W	Malnutrition	5B50-5B71	Approved	[4]

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L1-79	DMLHPVW	Autism spectrum disorder	6A02	Phase 2	[5]
OXB-102	DMXF9DM	Parkinson disease	8A00.0	Phase 1/2	[6]
ProSavin	DMJ42E6	Parkinson disease	8A00.0	Phase 1/2	[7]

5 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
3-chlorotyrosine	DMJ4SDM	Discovery agent	N.A.	Investigative	[8]
3-iodotyrosine	DMNZMH6	Discovery agent	N.A.	Investigative	[8]
7,8-dihydrobiopterin	DMQU4XM	Discovery agent	N.A.	Investigative	[9]
alpha-propyldopacetamide	DMQKMX3	Discovery agent	N.A.	Investigative	[8]
Meta-Tyrosine	DM0748C	Discovery agent	N.A.	Investigative	[9]

References

• [1] Selectivity and affinity determinants for ligand binding to the aromatic amino acid hydroxylases. Curr Med Chem. 2007;14(4):455-67.
• [2] Effect of metals and phenylalanine on the activity of human tryptophan hydroxylase-2: comparison with that on tyrosine hydroxylase activity. Neurosci Lett. 2006 Jul 3;401(3):261-5.
• [3] Dopamine beta-hydroxylase deficiency. A genetic disorder of cardiovascular regulation. Hypertension. 1991 Jul;18(1):1-8.
• [4] Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects. J Neural Transm Suppl. 2007;(72):113-20.
• [5] Effect of L1-79 on Core Symptoms of Autism Spectrum Disorder: A Case Series. Clin Ther. 2019 Oct;41(10):1972-1981.
• [6] Clinical pipeline report, company report or official report of Oxford BioMedica.
• [7] Clinical pipeline report, company report or official report of Oxford BioMedica.
• [8] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1243).
• [9] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.