Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTV1095)

• DTT Name: COVID-19 RNA-directed RNA polymerase (RdRp) DTT Info
• Gene Name: COVID-19 rep

Molecule-Related Drug & Molecule List

4 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Anidulafungin	DM8QM5U	Aspergillosis	1F20	Approved	[1]
Penciclovir	DMOUMDV	Herpes simplex labialis	1F00.01	Approved	[2]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[2]
Favipiravir	DMBZ27L	Influenza virus infection	1E30-1E32	Registered	[3]

1 Drugs in Phase 1 Trial Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Galidesivir	DMG9C4I	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 1 Trial	[4]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Suramin	DMTOUY9	African trypanosomiasis	1F51	Phase 1	[1]

References

• [1] Suramin, Penciclovir and Anidulafungin bind nsp12, which governs the RNA-dependent-RNA polymerase activity of SARS-CoV-2, with higher interaction energy than Remdesivir, indicating potential in the treatment of Covid-19 infection. April.21.2020. Doi: 10.31219/osf.io/urxwh
• [2] Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271.
• [3] Favipiravir versus Arbidol for COVID-19: A Randomized Clinical Trial. medRxiv. Posted April 15, 2020.
• [4] BioCryst Begins Clinical Trial with Galidesivir for Treatment of Patients with COVID-19