Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTV9GOF)

• DTT Name: Histidine decarboxylase (HDC) DTT Info
• Gene Name: HDC

Molecule-Related Drug & Molecule List

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lixivaptan	DMDN4ZP	Hyponatraemia	5C72	Phase 3	[1]
ALPHA-FMH	DMP9VXQ	Pruritus	EC90	Phase 1	[2]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMA	DM5JZUB	Discovery agent	N.A.	Investigative	[3]
Brocresine	DM9UF02	Discovery agent	N.A.	Investigative	[4]

References

• [1] Clinical pipeline report, company report or official report of Biofrontera (2009).
• [2] Alpha-Fluoromethylhistidine. Kinetics of uptake and inhibition of histamine synthesis in basophil (2H3) cell cultures. Mol Pharmacol. 1985 Aug;28(2):191-9.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1274).
• [4] Histamine in brain--its role in regulation of seizure susceptibility. Epilepsy Res. 1991 Nov-Dec;10(2-3):111-8.