Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTW38KT)

• DTT Name: Retinoic acid receptor alpha (RARA) DTT Info
• Gene Name: RARA

Molecule-Related Drug & Molecule List

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[1]
IRX-5183	DMCED9U	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]
SY-1425	DMH8UF0	Acute myeloid leukaemia	2A60	Phase 1	[3]

2 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID27336223-Compound-4	DMJFSOM	N. A.	N. A.	Patented	[4]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[4]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LG100268	DM41RK2	Acquired immune deficiency syndrome	1C62.3	Discontinued in Phase 1	[5]

8 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AGN193109	DMC0YOE	Discovery agent	N.A.	Investigative	[6]
AGN193836	DMEB93D	Discovery agent	N.A.	Investigative	[7]
BMS614	DMZWNO9	Discovery agent	N.A.	Investigative	[8]
BMS753	DMSX1NF	Discovery agent	N.A.	Investigative	[9]
CD666	DMC8X9Y	Discovery agent	N.A.	Investigative	[10]
Ro 40-6055	DMU2EKN	Discovery agent	N.A.	Investigative	[11]
Ro 41-5253	DMSJLWP	Discovery agent	N.A.	Investigative	[12]
Ro-40-0655	DM8PYAN	Colorectal cancer	2B91.Z	Investigative	[13]

References

• [1] Tamibarotene: a candidate retinoid drug for Alzheimer's disease. Biol Pharm Bull. 2012;35(8):1206-12.
• [2] Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat. J Mol Med (Berl). 2004 Feb;82(2):116-25.
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Therapeutic use of selective synthetic ligands for retinoic acid receptors: a patent review.Expert Opin Ther Pat. 2016 Aug;26(8):957-71.
• [5] Placental steroidogenesis in rats is independent of signaling pathways induced by retinoic acids. Gen Comp Endocrinol. 2009 Sep 15;163(3):285-91.
• [6] Therapeutic applications for ligands of retinoid receptors. Curr Pharm Des. 2000 Jan;6(1):25-58.
• [7] Synthesis and biological activity of retinoic acid receptor-alpha specific amides. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3145-8.
• [8] Co-regulator recruitment and the mechanism of retinoic acid receptor synergy. Nature. 2002 Jan 10;415(6868):187-92.
• [9] Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem Biol. 1999 Aug;6(8):519-29.
• [10] Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma. Biochem Biophys Res Commun. 1992 Jul 31;186(2):977-83.
• [11] Selective high affinity retinoic acid receptor alpha or beta-gamma ligands. Mol Pharmacol. 1991 Oct;40(4):556-62.
• [12] A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7129-33.
• [13] Tamibarotene. Drugs Today (Barc). 2007 Aug;43(8):563-8.