Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTWMIDN)

• DTT Name: B-cell-activating factor (TNFSF13B) DTT Info
• Gene Name: TNFSF13B

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Belimumab	DM3OBQF	Membranous glomerulonephritis		Approved	[1]

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Blisibimod	DM7V9LH	Systemic lupus erythematosus	4A40.0	Phase 3	[2]
Tabalumab	DMKSAG1	Multiple myeloma	2A83	Phase 3	[3]
AMG 570	DMY1XJH	Systemic lupus erythematosus	4A40.0	Phase 2	[4]

2 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BR3-Fc	DMFN1WI	Idiopathic thrombocytopenic purpura	3B64.10	Discontinued in Phase 2	[5]
LymphoRad-131	DMDUM0Z	Lymphoma	2A80-2A86	Discontinued in Phase 1	[6]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1,4-Diethylene Dioxide	DMI36WC	Discovery agent	N.A.	Investigative	[7]
Receptor-Fc fusion proteins	DM4B6FO	Discovery agent	N.A.	Investigative	[8]

References

• [1] Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Tabalumab, an anti-BAFF monoclonal antibody, in patients with active rheumatoid arthritis with an inadequate response to TNF inhibitors. Ann Rheum Dis. 2013 Sep 1;72(9):1461-8.
• [4] Development of an ICOSL and BAFF bispecific inhibitor AMG 570 for systemic lupus erythematosus treatment. Clin Exp Rheumatol. Nov-Dec 2019;37(6):906-914.
• [5] Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54.
• [6] Fusion Toxin BLyS-Gelonin Inhibits Growth of Malignant Human B Cell Lines In Vitro and In Vivo. PLoS One. 2012; 7(10): e47361.
• [7] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
• [8] BAFF: B cell survival factor and emerging therapeutic target for autoimmune disorders. Expert Opin Ther Targets. 2003 Feb;7(1):115-23.