Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTX20QP)

• DTT Name: Geranylgeranyl transferase I (GGTase-I) DTT Info
• Gene Name: PGGT1B

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-778123	DMWSC5L	Lymphoma	2A80-2A86	Phase 1	[1]

2 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GGTI-298	DM1CG0J	N. A.	N. A.	Terminated	[2]
L-745631	DM4UP7R	Solid tumour/cancer	2A00-2F9Z	Terminated	[3]

4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
A-313326	DML4P6O	Discovery agent	N.A.	Investigative	[4]
J-109,390	DM9SFGB	Discovery agent	N.A.	Investigative	[5]
L-269,289	DMV6018	Discovery agent	N.A.	Investigative	[5]
PD-83176	DMSIMKZ	Discovery agent	N.A.	Investigative	[6]

References

• [1] Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein trans... Mol Cancer Ther. 2002 Jul;1(9):747-58.
• [2] The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner. J Biol Chem. 1997 Oct 24;272(43):27224-9.
• [3] Ras farnesyltransferase: a new therapeutic target. J Med Chem. 1997 Sep 12;40(19):2971-90.
• [4] Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase. Bioorg Med Chem Lett. 2005 Jan 3;15(1):153-8.
• [5] Geranylgeranyltransferase I of Candida albicans: null mutants or enzyme inhibitors produce unexpected phenotypes. J Bacteriol. 2000 Feb;182(3):704-13.
• [6] Structure-activity relationships of cysteine-lacking pentapeptide derivatives that inhibit ras farnesyltransferase. J Med Chem. 1997 Jan 17;40(2):192-200.