Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTXMNHO)

• DTT Name: Plasmodium Plasmepsin 2 (Malaria PLA2) DTT Info
• Gene Name: Malaria PLA2

Molecule-Related Drug & Molecule List

3 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9353089, 135	DMWG98Z	N. A.	N. A.	Patented	[1]
US9353089, 327	DMB4MJ0	N. A.	N. A.	Patented	[1]
US9353089, 330	DMK02LS	N. A.	N. A.	Patented	[1]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pepstatin	DM9S1EA	Malaria	1F40-1F45	Terminated	[2]

69 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
E-64	DMMOPAK	Discovery agent	N.A.	Investigative	[3]
KNI-10006	DMMISH6	Discovery agent	N.A.	Investigative	[4]
KNI-10033	DMLOXMQ	Discovery agent	N.A.	Investigative	[5]
KNI-10061	DMMZ6AO	Discovery agent	N.A.	Investigative	[5]
KNI-10062	DMYSDN4	Discovery agent	N.A.	Investigative	[5]
KNI-10074	DMM5SDT	Discovery agent	N.A.	Investigative	[6]
KNI-10079	DMCZOX9	Discovery agent	N.A.	Investigative	[6]
KNI-10080	DMEN4DZ	Discovery agent	N.A.	Investigative	[6]
KNI-10081	DM1Z7QK	Discovery agent	N.A.	Investigative	[6]
KNI-10087	DMYN2U4	Discovery agent	N.A.	Investigative	[6]
KNI-10088	DM4GASE	Discovery agent	N.A.	Investigative	[6]
KNI-10092	DMV1KI2	Discovery agent	N.A.	Investigative	[6]
KNI-10093	DMGY5Z0	Discovery agent	N.A.	Investigative	[6]
KNI-10094	DMJIQG2	Discovery agent	N.A.	Investigative	[6]
KNI-10095	DMEHPVF	Discovery agent	N.A.	Investigative	[6]
KNI-10106	DMBTRHG	Discovery agent	N.A.	Investigative	[6]
KNI-10113	DM78A6F	Discovery agent	N.A.	Investigative	[6]
KNI-10124	DMA9104	Discovery agent	N.A.	Investigative	[6]
KNI-10125	DMDBERC	Discovery agent	N.A.	Investigative	[6]
KNI-10152	DMNBUS4	Discovery agent	N.A.	Investigative	[6]
KNI-10155	DM1PKWA	Discovery agent	N.A.	Investigative	[6]
KNI-10216	DM64NBG	Discovery agent	N.A.	Investigative	[6]
KNI-10217	DMHLFAE	Discovery agent	N.A.	Investigative	[6]
KNI-10232	DMQY1ST	Discovery agent	N.A.	Investigative	[5]
KNI-10255	DMV3U9Z	Discovery agent	N.A.	Investigative	[6]
KNI-10256	DMZFVHT	Discovery agent	N.A.	Investigative	[6]
KNI-10260	DMZXI6U	Discovery agent	N.A.	Investigative	[6]
KNI-10265	DMQLB3T	Discovery agent	N.A.	Investigative	[6]
KNI-10266	DMP2E3I	Discovery agent	N.A.	Investigative	[6]
KNI-10282	DMAR35H	Discovery agent	N.A.	Investigative	[6]
KNI-10283	DMGVBIT	Discovery agent	N.A.	Investigative	[6]
KNI-10313	DMP7M8O	Discovery agent	N.A.	Investigative	[5]
KNI-10314	DMYGNZA	Discovery agent	N.A.	Investigative	[5]
KNI-10315	DM1OPYT	Discovery agent	N.A.	Investigative	[5]
KNI-10316	DMMIDCG	Discovery agent	N.A.	Investigative	[5]
KNI-10332	DMKVPMS	Discovery agent	N.A.	Investigative	[5]
KNI-10341	DMF9P25	Discovery agent	N.A.	Investigative	[5]
KNI-10342	DMDM5BL	Discovery agent	N.A.	Investigative	[5]
KNI-10368	DM8SIRL	Discovery agent	N.A.	Investigative	[5]
KNI-10369	DM97STY	Discovery agent	N.A.	Investigative	[6]
KNI-10372	DM4AUCE	Discovery agent	N.A.	Investigative	[5]
KNI-10526	DMEN2L3	Discovery agent	N.A.	Investigative	[6]
KNI-10527	DMU4K7O	Discovery agent	N.A.	Investigative	[6]
KNI-10529	DMDRWYG	Discovery agent	N.A.	Investigative	[6]
KNI-10538	DM7XEIY	Discovery agent	N.A.	Investigative	[4]
KNI-10539	DMLWOFY	Discovery agent	N.A.	Investigative	[6]
KNI-10541	DMP87U4	Discovery agent	N.A.	Investigative	[6]
KNI-10737	DMGUABP	Discovery agent	N.A.	Investigative	[4]
KNI-10740	DMPWY6H	Discovery agent	N.A.	Investigative	[4]
KNI-10741	DM7TW4C	Discovery agent	N.A.	Investigative	[4]
KNI-10742	DM4D9T3	Discovery agent	N.A.	Investigative	[4]
KNI-10743	DM0VSPE	Discovery agent	N.A.	Investigative	[4]
KNI-10758	DMM2A5Q	Discovery agent	N.A.	Investigative	[4]
KNI-10759	DMAF1W3	Discovery agent	N.A.	Investigative	[4]
KNI-10760	DMT5FIP	Discovery agent	N.A.	Investigative	[4]
KNI-10761	DMXUTWZ	Discovery agent	N.A.	Investigative	[4]
KNI-10762	DM73WB2	Discovery agent	N.A.	Investigative	[4]
KNI-10763	DMKAY5G	Discovery agent	N.A.	Investigative	[4]
KNI-1293	DMZX430	Discovery agent	N.A.	Investigative	[6]
KNI-227	DMS61DB	Discovery agent	N.A.	Investigative	[5]
KNI-727	DM105NU	Discovery agent	N.A.	Investigative	[7]
Leupeptin	DMU075F	Malaria	1F40-1F45	Investigative	[2]
N-(R-Carboxy-Ethyl)-Alpha-(S)-(2-Phenylethyl)	DM2SNXB	Discovery agent	N.A.	Investigative	[8]
PS-154636-1	DMQUG0K	Discovery agent	N.A.	Investigative	[9]
PS-222036	DMQVI5U	Discovery agent	N.A.	Investigative	[9]
PS-444035	DMH8YMP	Discovery agent	N.A.	Investigative	[9]
PS-662477	DMT4YFR	Discovery agent	N.A.	Investigative	[9]
PS-725074	DM05DOF	Discovery agent	N.A.	Investigative	[9]
PS-777621	DM3F7SD	Discovery agent	N.A.	Investigative	[10]

References

• [1] Compositions and methods for the treatment of malaria. US9353089.
• [2] Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10.
• [3] Antimalarial synergy of cysteine and aspartic protease inhibitors. Antimicrob Agents Chemother. 1998 Sep;42(9):2254-8.
• [4] Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4836-9.
• [5] Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3048-52.
• [6] Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60.
• [7] Identification and characterization of allophenylnorstatine-based inhibitors of plasmepsin II, an antimalarial target. Biochemistry. 2002 Feb 19;41(7):2273-80.
• [8] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [9] Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library. Bioorg Med Chem Lett. 1998 Sep 8;8(17):2315-20.
• [10] High antiplasmodial activity of novel plasmepsins I and II inhibitors. J Med Chem. 2006 Dec 14;49(25):7440-9.