Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTY84UG)

• DTT Name: Acetyl-CoA carboxylase 2 (ACACB) DTT Info
• Gene Name: ACACB

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metformin	DM89QE1	Colorectal carcinoma		Approved	[1]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PF-05175157	DMLQ3OK	Type-2 diabetes	5A11	Phase 2	[2]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Axokine	DMT5O8I	Obesity	5B81	Discontinued in Phase 3	[3]

6 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-[4-(2,4-Dichlorophenoxy)Phenoxy]Propanoic Acid	DMWXI06	Discovery agent	N.A.	Investigative	[4]
A-80040	DML20N9	Discovery agent	N.A.	Investigative	[5]
AC-8632	DM09BJ4	Parkinson disease	8A00.0	Investigative	[2]
CP-640186	DMO0PS9	Discovery agent	N.A.	Investigative	[6]
QLT-091382	DMWOSFJ	Sebaceous gland disease	EM0Z	Investigative	[2]
Soraphen A	DM18IKZ	Discovery agent	N.A.	Investigative	[7]

References

• [1] AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C. Biochem Pharmacol. 2009 Jun 1;77(11):1684-93.
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1264).
• [3] Obesity: pathophysiology and clinical management. Curr Med Chem. 2009;16(4):506-21.
• [4] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [5] Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acet... J Med Chem. 2006 Jun 29;49(13):3770-3.
• [6] (4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6645-8.
• [7] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.