Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTZFTY4)

• DTT Name: Amidophosphoribosyltransferase (PPAT) DTT Info
• Gene Name: PPAT

Molecule-Related Drug & Molecule List

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[1]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[2]

4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
6-Chloropurine Riboside, 5'-Monophosphate	DMWB43U	Discovery agent	N.A.	Investigative	[3]
Mycophenolic bis(sulfonamide)	DMUQP3J	Discovery agent	N.A.	Investigative	[4]
Mycophenolic hydroxamic acid	DM4YRAH	Discovery agent	N.A.	Investigative	[5]
Tiazofurin adenine dinucleotide	DMEFVPH	Discovery agent	N.A.	Investigative	[6]

References

• [1] IMPDH activity in thiopurine-treated patients with inflammatory bowel disease - relation to TPMT activity and metabolite concentrations. Br J Clin Pharmacol. 2008 Jan;65(1):69-77.
• [2] 6-mercaptopurine (6-MP) induces p53-mediated apoptosis of neural progenitor cells in the developing fetal rodent brain. Neurotoxicol Teratol. 2009 Jul-Aug;31(4):198-202.
• [3] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [4] Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase. Bioorg Med Chem. 2008 Aug 1;16(15):7462-9.
• [5] Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells among the mycoph... Bioorg Med Chem. 2010 Nov 15;18(22):8106-11.
• [6] Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment. J Med Chem. 2007 Dec 27;50(26):6685-91.