TTD | Drug: D00AAN

Drug General Information
Drug ID	D00AAN
Former ID	DNC008068
Drug Name	8-O-(4-chlorobenzenesulfonyl)manzamine F
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528991]
Formula	C42H47ClN4O5S
Canonical SMILES	C1CCN2CCC3C(=CC(CCC=CC1)(C4C3(C2)CC5N4CCCC(=O)CC5)O)C6=<br />NC=CC7=C6NC8=C7C=CC=C8OS(=O)(=O)C9=CC=C(C=C9)Cl
InChI	1S/C42H47ClN4O5S/c43-28-12-16-31(17-13-28)53(50,51)52-36-11-7-10-32-33-18-21-44-38(39(33)45-37(32)36)34-26-42(49)20-5-3-1-2-4-6-22-46-24-19-35(34)41(27-46)25-29-14-15-30(48)9-8-23-47(29)40(41)42/h1,3,7,10-13,16-18,21,26,29,35,40,45,49H,2,4-6,8-9,14-15,19-20,22-25,27H2/b3-1-/t29-,35?,40+,41-,42-/m0/s1
InChIKey	MSUMHGMGRZWLMN-WXPZYUJUSA-N
PubChem Compound ID	23643731
Target and Pathway
Target(s)	Glycogen synthase kinase-3 beta	Target Info	Inhibitor	[528991]
KEGG Pathway	ErbB signaling pathway
	Chemokine signaling pathway
	Cell cycle
	PI3K-Akt signaling pathway
	Wnt signaling pathway
	Hedgehog signaling pathway
	Axon guidance
	Hippo signaling pathway
	Focal adhesion
	Signaling pathways regulating pluripotency of stem cells
	T cell receptor signaling pathway
	B cell receptor signaling pathway
	Neurotrophin signaling pathway
	Dopaminergic synapse
	Insulin signaling pathway
	Melanogenesis
	Prolactin signaling pathway
	Thyroid hormone signaling pathway
	Non-alcoholic fatty liver disease (NAFLD)
	Alzheimer's disease
	Hepatitis C
	Measles
	Influenza A
	HTLV-I infection
	Epstein-Barr virus infection
	Pathways in cancer
	Colorectal cancer
	Endometrial cancer
	Prostate cancer
	Basal cell carcinoma
PANTHER Pathway	Alzheimer disease-presenilin pathway
	Angiogenesis
	Cadherin signaling pathway
	Hedgehog signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Insulin/IGF pathway-protein kinase B signaling cascade
	Interleukin signaling pathway
	PDGF signaling pathway
	PI3 kinase pathway
	Wnt signaling pathway
	Ras Pathway
	CCKR signaling map ST
Pathway Interaction Database	LPA receptor mediated events
	Degradation of beta catenin
	Reelin signaling pathway
	Presenilin action in Notch and Wnt signaling
	Integrin-linked kinase signaling
	CDC42 signaling events
	LKB1 signaling events
	Canonical Wnt signaling pathway
	Role of Calcineurin-dependent NFAT signaling in lymphocytes
	Glucocorticoid receptor regulatory network
	C-MYC pathway
	Regulation of Androgen receptor activity
	BMP receptor signaling
	Hedgehog signaling events mediated by Gli proteins
	Signaling events mediated by Stem cell factor receptor (c-Kit)
	Validated transcriptional targets of deltaNp63 isoforms
	Aurora A signaling
	Insulin-mediated glucose transport
	Class I PI3K signaling events mediated by Akt
	p53 pathway
	Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome	Degradation of beta-catenin by the destruction complex
	AKT phosphorylates targets in the cytosol
	Regulation of HSF1-mediated heat shock response
	CRMPs in Sema3A signaling
	Disassembly of the destruction complex and recruitment of AXIN to the membrane
	S33 mutants of beta-catenin aren't phosphorylated
	S37 mutants of beta-catenin aren't phosphorylated
	S45 mutants of beta-catenin aren't phosphorylated
	T41 mutants of beta-catenin aren't phosphorylated
	Degradation of GLI2 by the proteasome
	Constitutive Signaling by AKT1 E17K in Cancer
WikiPathways	DNA Damage Response (only ATM dependent)
	Senescence and Autophagy in Cancer
	Notch Signaling Pathway
	Glycogen Metabolism
	Insulin Signaling
	Wnt Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	IL-6 signaling pathway
	Wnt Signaling Pathway Netpath
	Copper homeostasis
	Focal Adhesion
	Hair Follicle Development: Induction (Part 1 of 3)
	Cardiac Hypertrophic Response
	Degradation of beta-catenin by the destruction complex
	T-Cell Receptor and Co-stimulatory Signaling
	Cardiac Progenitor Differentiation
	BDNF signaling pathway
	Corticotropin-releasing hormone
	B Cell Receptor Signaling Pathway
	IL17 signaling pathway
	Neural Crest Differentiation
	Alzheimers Disease
	IL-7 Signaling Pathway
	Regulation of Microtubule Cytoskeleton
	TWEAK Signaling Pathway
	Leptin signaling pathway
	Semaphorin interactions
	Cell Cycle
	MicroRNAs in cardiomyocyte hypertrophy
	Androgen receptor signaling pathway
	IL-5 Signaling Pathway
References
Ref 528991	J Nat Prod. 2007 Sep;70(9):1397-405. Epub 2007 Aug 21.Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease.
Ref 528991	J Nat Prod. 2007 Sep;70(9):1397-405. Epub 2007 Aug 21.Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease.

Drug Information