Drug Information

Drug General Information
Drug ID
D00SAA
Former ID
DNC006426
Drug Name
3-isopropylnaphthalene-1,2-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527986]
Formula
C13H12O2
Canonical SMILES
CC(C)C1=CC2=CC=CC=C2C(=O)C1=O
InChI
1S/C13H12O2/c1-8(2)11-7-9-5-3-4-6-10(9)12(14)13(11)15/h3-8H,1-2H3
InChIKey
KGCDZSGUSQQVKL-UHFFFAOYSA-N
PubChem Compound ID
14828129
Target and Pathway
Target(s) M-phase inducer phosphatase 1 Target Info Inhibitor [527986]
KEGG Pathway Cell cycle
Progesterone-mediated oocyte maturation
MicroRNAs in cancer
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database E2F transcription factor network
ATR signaling pathway
Validated targets of C-MYC transcriptional activation
ATM pathway
Reactome E2F mediated regulation of DNA replication
G0 and Early G1
Polo-like kinase mediated events
Cyclin B2 mediated events
Activation of ATR in response to replication stress
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
Cyclin A/B1 associated events during G2/M transition
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Cyclin A:Cdk2-associated events at S phase entry
WikiPathways DNA Damage Response
G1 to S cell cycle control
S Phase
ATM Signaling Pathway
Retinoblastoma (RB) in Cancer
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Mitotic G1-G1/S phases
Cell Cycle
Cell Cycle Checkpoints
miRNAs involved in DNA damage response
miRNA Regulation of DNA Damage Response
References
Ref 527986Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.
Ref 527986Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.