Drug Information

Drug General Information
Drug ID
D00TDJ
Former ID
DNC007736
Drug Name
1-(2-amino-benzothiazol-5-yl)-2-ethyl-isothiourea
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528695]
Formula
C10H12N4S2
Canonical SMILES
CCSC(=NC1=CC2=C(C=C1)SC(=N2)N)N
InChI
1S/C10H12N4S2/c1-2-15-9(11)13-6-3-4-8-7(5-6)14-10(12)16-8/h3-5H,2H2,1H3,(H2,11,13)(H2,12,14)
InChIKey
NXVMLACGHCLFBM-UHFFFAOYSA-N
PubChem Compound ID
44430622
Target and Pathway
Target(s) Nitric-oxide synthase, endothelial Target Info Inhibitor [528695]
Nitric-oxide synthase, brain Target Info Inhibitor [528695]
BioCyc Pathway Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cycle
KEGG Pathway Arginine and proline metabolism
Metabolic pathways
Calcium signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
Sphingolipid signaling pathway
PI3K-Akt signaling pathway
VEGF signaling pathway
Platelet activation
Estrogen signaling pathway
Oxytocin signaling pathwayhsa00330:Arginine and proline metabolism
Phagosome
Circadian entrainment
Long-term depression
Salivary secretion
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
NetPath Pathway Wnt Signaling PathwayNetPath_4:EGFR1 Signaling Pathway
PANTHER Pathway Angiogenesis
Endothelin signaling pathway
Interleukin signaling pathway
PI3 kinase pathway
VEGF signaling pathwayP06959:CCKR signaling map ST
Pathway Interaction Database Plasma membrane estrogen receptor signaling
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Angiopoietin receptor Tie2-mediated signaling
Thromboxane A2 receptor signaling
SHP2 signaling
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2
PAR1-mediated thrombin signaling events
PathWhiz Pathway Arginine and Proline Metabolism
Reactome ROS production in response to bacteria
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
eNOS activation
Nitric oxide stimulates guanylate cyclase
VEGFR2 mediated vascular permeabilityR-HSA-1222556:ROS production in response to bacteria
WikiPathways ACE Inhibitor Pathway
EGF/EGFR Signaling Pathway
Myometrial Relaxation and Contraction Pathways
JAK/STAT
Corticotropin-releasing hormone
AGE/RAGE pathway
Endothelin Pathways
Leptin signaling pathway
Effects of Nitric Oxide
Metabolism of nitric oxide
AngiogenesisWP727:Monoamine Transport
Amyotrophic lateral sclerosis (ALS)
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Spinal Cord Injury
Alzheimers Disease
Serotonin Transporter Activity
References
Ref 528695Bioorg Med Chem Lett. 2007 May 1;17(9):2540-4. Epub 2007 Feb 8.Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors.
Ref 528695Bioorg Med Chem Lett. 2007 May 1;17(9):2540-4. Epub 2007 Feb 8.Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors.