Drug General Information
Drug ID
D01BCK
Former ID
DNC013435
Drug Name
N-hydroxy-1-naphthamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528719]
Formula
C11H9NO2
Canonical SMILES
C1=CC=C2C(=C1)C=CC=C2C(=O)NO
InChI
1S/C11H9NO2/c13-11(12-14)10-7-3-5-8-4-1-2-6-9(8)10/h1-7,14H,(H,12,13)
InChIKey
JRZGPWOEHDOVMC-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Histone Deacetylase 8 Target Info Inhibitor [528719]
KEGG Pathway Alcoholism
Viral carcinogenesis
PANTHER Pathway Wnt signaling pathway
Pathway Interaction Database Signaling events mediated by HDAC Class I
Reactome NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
WikiPathways Integrated Pancreatic Cancer Pathway
Neural Crest Differentiation
Cell Cycle
References
Ref 528719Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8. Epub 2007 Feb 25.Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors.
Ref 528719Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8. Epub 2007 Feb 25.Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors.