Drug Information

Drug General Information
Drug ID
D01JUI
Former ID
DNC004613
Drug Name
N-(4-Chloro-7-p-tolyl-isoquinolin-1-yl)-guanidine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527081]
Formula
C17H15ClN4
Canonical SMILES
CC1=CC=C(C=C1)C2=CC3=C(C=C2)C(=CN=C3N=C(N)N)Cl
InChI
1S/C17H15ClN4/c1-10-2-4-11(5-3-10)12-6-7-13-14(8-12)16(22-17(19)20)21-9-15(13)18/h2-9H,1H3,(H4,19,20,21,22)
InChIKey
CHWRGRHMWONZIO-UHFFFAOYSA-N
PubChem Compound ID
44339119
Target and Pathway
Target(s) Tissue-type plasminogen activator Target Info Inhibitor [527081]
Plasminogen Target Info Inhibitor [527081]
KEGG Pathway Complement and coagulation cascades
Transcriptional misregulation in cancerhsa04080:Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
Influenza A
NetPath Pathway IL5 Signaling Pathway
PANTHER Pathway Blood coagulation
Plasminogen activating cascadeP00011:Blood coagulation
Plasminogen activating cascade
Pathway Interaction Database amb2 Integrin signaling
Beta2 integrin cell surface interactionsangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling
p75(NTR)-mediated signaling
Syndecan-4-mediated signaling events
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
PathWhiz Pathway CoagulationPW000562:Coagulation
Reactome Dissolution of Fibrin ClotR-HSA-114608:Platelet degranulation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Dissolution of Fibrin Clot
WikiPathways Senescence and Autophagy in Cancer
Complement and Coagulation Cascades
Endochondral Ossification
Blood Clotting Cascade
Dissolution of Fibrin Clot
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient NetworkWP558:Complement and Coagulation Cascades
Human Complement System
Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Activation of Matrix Metalloproteinases
Selenium Micronutrient Network
References
Ref 527081Bioorg Med Chem Lett. 2004 Jun 21;14(12):3227-30.Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-isoquinolinylguanidines.
Ref 527081Bioorg Med Chem Lett. 2004 Jun 21;14(12):3227-30.Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-isoquinolinylguanidines.