Drug Information

Drug General Information
Drug ID
D01NTY
Former ID
DNC003119
Drug Name
8-Iodo-Guanine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551393]
Formula
C5H4IN5O
Canonical SMILES
C12=C(NC(=NC1=O)N)N=C(N2)I
InChI
1S/C5H4IN5O/c6-4-8-1-2(9-4)10-5(7)11-3(1)12/h(H4,7,8,9,10,11,12)
InChIKey
SXGFECRAKVVEJT-UHFFFAOYSA-N
PubChem Compound ID
444737
PubChem Substance ID
830554, 6590921, 6730836, 7885534, 14795504, 36887658, 46391614, 46507908, 53121883, 57245710, 104632763, 129301897, 136038843, 137264928, 227116113
Target and Pathway
Target(s) Purine nucleoside phosphorylase Target Info Inhibitor [551393]
BioCyc Pathway Arsenate detoxification I (glutaredoxin)
Purine nucleotides degradation
Urate biosynthesis/inosine 5'-phosphate degradation
Purine deoxyribonucleosides degradation
Purine ribonucleosides degradation to ribose-1-phosphate
Guanosine nucleotides degradation
Adenosine nucleotides degradation
Superpathway of purine nucleotide salvage
Adenine and adenosine salvage III
Guanine and guanosine salvage
KEGG Pathway Purine metabolism
Pyrimidine metabolism
Nicotinate and nicotinamide metabolism
Metabolic pathways
NetPath Pathway TCR Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Adenine and hypoxanthine salvage pathway
Xanthine and guanine salvage pathway
PathWhiz Pathway Purine Metabolism
Nicotinate and Nicotinamide Metabolism
Reactome Purine salvage
Purine catabolism
WikiPathways miR-targeted genes in squamous cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
Metabolism of nucleotides
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.