Drug Information

Drug General Information
Drug ID
D01UZT
Former ID
DNC012974
Drug Name
4-(4-chlorophenyl)-1-pyrid-2-yl-pyrazole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528080]
Formula
C14H10ClN3
Canonical SMILES
C1=CC=NC(=C1)N2C=C(C=N2)C3=CC=C(C=C3)Cl
InChI
1S/C14H10ClN3/c15-13-6-4-11(5-7-13)12-9-17-18(10-12)14-3-1-2-8-16-14/h1-10H
InChIKey
NJMIDEUMQUSYDE-UHFFFAOYSA-N
PubChem Compound ID
44408653
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [528080]
Gamma-aminobutyric acid receptor subunit beta-2 Target Info Inhibitor [528080]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [528080]
Gamma-aminobutyric acid receptor Target Info Inhibitor [528080]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Serotonergic synapse
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 528080J Med Chem. 2006 Mar 23;49(6):1855-66.Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.
Ref 528080J Med Chem. 2006 Mar 23;49(6):1855-66.Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.