Drug Information

Drug General Information
Drug ID
D01YOC
Former ID
DIB006240
Drug Name
BMS-181100
Synonyms
BMY-14786; BMY-14802; BMY-14802 hydrochloride; MJ-14676; MJ-14786; MJ-14802; BMY-14802, Skybridge; BMY-14802-1; BMY-14802 (dyskinesia), Skybridge; 5-HT 1a receptor agonist (dyskinesia), Skybridge
Drug Type
Small molecular drug
Indication Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] Discontinued in Phase 3 [542913], [544706]
Company
Bristol-Myers Squibb Co; Skybridge Pharmaceuticals Inc
Formula
C18H22F2N4O
InChI
InChI=1S/C18H22F2N4O/c19-15-5-3-14(4-6-15)17(25)2-1-7-23-8-10-24(11-9-23)18-21-12-16(20)13-22-18/h3-6,12-13,17,25H,1-2,7-11H2
InChIKey
ZXUYYZPJUGQHLQ-UHFFFAOYSA-N
PubChem Compound ID
108046
PubChem Substance ID
6644759, 10234568, 14851854, 44436951, 47880017, 48179629, 50070397, 50071041, 57338406, 76749565, 85229948, 85788147, 103248082, 103916544, 104380366, 126431567, 129970567, 134224547, 135065250, 135650007, 137129163, 140448622, 162220534, 226785221
Target and Pathway
Target(s) Sigma(1)-type opioid receptor Target Info Modulator
5-hydroxytryptamine 1A receptor Target Info Modulator
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways miR-targeted genes in squamous cell - TarBase
miR-targeted genes in lymphocytes - TarBaseWP722:Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 542913(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8).
Ref 544706Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000679)