Drug Information

Drug General Information
Drug ID
D02CTS
Former ID
DCL001219
Drug Name
Ospemifene
Drug Type
Small molecular drug
Indication Dyspareunia [ICD10:N94.1] Approved [532651], [542369]
Post-menopausal vaginal atrophy [ICD9: 627.3; ICD10:N95.2] Phase 3 [542369], [551684]
Company
Shionogi; QuatRx
Formula
C24H23ClO2
InChI
InChI=1S/C24H23ClO2/c25-16-15-23(19-7-3-1-4-8-19)24(20-9-5-2-6-10-20)21-11-13-22(14-12-21)27-18-17-26/h1-14,26H,15-18H2/b24-23-
InChIKey
LUMKNAVTFCDUIE-VHXPQNKSSA-N
CAS Number
CAS 128607-22-7
PubChem Compound ID
3036505
PubChem Substance ID
10048556, 12015426, 14804521, 36104653, 53788245, 57353466, 77768422, 96025641, 111641440, 135106463, 137013915, 142415636, 160708695, 162169319, 175267362, 175426911, 178103921, 179149775, 198991711, 201248858, 224253139, 227208701, 249583801, 251916528, 251917875, 252215972, 252430798, 252472856
SuperDrug ATC ID
G03XC05
Target and Pathway
Target(s) Estrogen receptor Target Info Modulator [551684]
KEGG Pathway Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Proteoglycans in cancer
NetPath Pathway FSH Signaling Pathway
EGFR1 Signaling Pathway
RANKL Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
Plasma membrane estrogen receptor signaling
LKB1 signaling events
Regulation of Telomerase
ATF-2 transcription factor network
AP-1 transcription factor network
FOXM1 transcription factor network
Validated nuclear estrogen receptor alpha network
Signaling mediated by p38-alpha and p38-beta
FOXA1 transcription factor network
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Estrogen signaling pathway
Nuclear Receptors Meta-Pathway
Estrogen Receptor Pathway
Signaling by ERBB4
JAK/STAT
Integrated Pancreatic Cancer Pathway
Leptin signaling pathway
miR-targeted genes in muscle cell - TarBase
Integrated Breast Cancer Pathway
Nuclear Receptors
References
Ref 5326512013 FDA drug approvals. Nat Rev Drug Discov. 2014 Feb;13(2):85-9.
Ref 542369(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7349).
Ref 551684Clinical pipeline report, company report or official report of Shionogi (2011).
Ref 551684Clinical pipeline report, company report or official report of Shionogi (2011).