Drug Information

Drug General Information
Drug ID
D02GOH
Former ID
DNC006015
Drug Name
AM-404
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534262]
Formula
C26H37NO2
Canonical SMILES
CCCCCC=CCC=CCC=CCC=CCCCC(=O)NC1=CC=C(C=C1)O
InChI
1S/C26H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-26(29)27-24-20-22-25(28)23-21-24/h6-7,9-10,12-13,15-16,20-23,28H,2-5,8,11,14,17-19H2,1H3,(H,27,29)/b7-6+,10-9+,13-12+,16-15+
InChIKey
IJBZOOZRAXHERC-CGRWFSSPSA-N
PubChem Compound ID
6604822
Target and Pathway
Target(s) Cannabinoid receptor 2 Target Info Inhibitor [529838]
Cannabinoid receptor 1 Target Info Inhibitor [534262]
Fatty-acid amide hydrolase Target Info Inhibitor [529838]
BioCyc Pathway Anandamide degradation
KEGG Pathway Neuroactive ligand-receptor interactionhsa04015:Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signalinghsa04723:Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signalingP05728:Anandamide degradation
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
BDNF signaling pathway
GPCR downstream signaling
GPCRs, Other
References
Ref 534262J Med Chem. 1996 Oct 25;39(22):4515-9.Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand.
Ref 529838J Med Chem. 2008 Dec 25;51(24):7800-5.New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide.
Ref 534262J Med Chem. 1996 Oct 25;39(22):4515-9.Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand.