Drug Information

Drug General Information
Drug ID
D02LHR
Former ID
DNC003773
Drug Name
INDORAMIN
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Withdrawn from market [468125], [551871]
Formula
C22H25N3O
InChI
InChI=1S/C22H25N3O/c26-22(17-6-2-1-3-7-17)24-19-11-14-25(15-12-19)13-10-18-16-23-21-9-5-4-8-20(18)21/h1-9,16,19,23H,10-15H2,(H,24,26)
InChIKey
JXZZEXZZKAWDSP-UHFFFAOYSA-N
CAS Number
CAS 26844-12-2
PubChem Compound ID
33625
PubChem Substance ID
3145511, 4954321, 7979608, 8173213, 11393053, 14778365, 26534678, 29217568, 34675413, 47206378, 47227712, 47301929, 47451424, 47747528, 47971029, 48345790, 49671666, 49876989, 50603739, 57311546, 85209952, 89765137, 92270335, 103006849, 103194521, 103941454, 104316511, 117564550, 124638943, 125163373, 125433253, 128343844, 134224549, 134340978, 134997857, 135650391, 136050062, 137248543, 141645446, 152133947, 162185578, 179150251, 184547504, 187071875, 198950576, 223519058, 224810415, 226433258, 226433259, 241046546
SuperDrug ATC ID
C02CA02
Target and Pathway
Target(s) Alpha-1D adrenergic receptor Target Info Inhibitor [533682]
Alpha-2C adrenergic receptor Target Info Inhibitor [533682]
Alpha-2B adrenergic receptor Target Info Inhibitor [533682]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR downstream signalingWP58:Monoamine GPCRs
References
Ref 468125(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 501).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 533682J Med Chem. 1995 Sep 1;38(18):3415-44.Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.