TTD | Drug: D02OZK

Drug General Information
Drug ID	D02OZK
Former ID	DNCL002475
Drug Name	Obatoclax
Drug Type	Small molecular drug
Indication	Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48]		Phase 2	[531104]
Company	Cephalon
Formula	C20H19N3O
Canonical SMILES	CC1=CC(=C(N1)C=C2C(=CC(=C3C=C4C=CC=CC4=N3)N2)OC)C
InChI	1S/C20H19N3O/c1-12-8-13(2)21-16(12)10-19-20(24-3)11-18(23-19)17-9-14-6-4-5-7-15(14)22-17/h4-11,21,23H,1-3H3/b18-17-,19-10-
InChIKey	CVCLJVVBHYOXDC-IAZSKANUSA-N
PubChem Compound ID	11404337
PubChem Substance ID	16499856, 42483480, 78122656, 103566283, 141750445, 160855985, 163657578, 177748730, 198960139, 226931860
Drug Resistance Mutation (DRM)
DRM	DRM Info
Target and Pathway
Target(s)	Apoptosis regulator Bcl-2	Target Info	Inhibitor	[531104]
	Antiapoptotic protein BCL-XL	Target Info	Inhibitor	[531104]
	Induced myeloid leukemia cell differentiation protein Mcl-1	Target Info	Inhibitor	[531104]
KEGG Pathway	NF-kappa B signaling pathway
	HIF-1 signaling pathway
	Sphingolipid signaling pathway
	Protein processing in endoplasmic reticulum
	PI3K-Akt signaling pathway
	Apoptosis
	Adrenergic signaling in cardiomyocytes
	Focal adhesion
	Neurotrophin signaling pathway
	Cholinergic synapse
	Amyotrophic lateral sclerosis (ALS)
	Toxoplasmosis
	Tuberculosis
	Hepatitis B
	Epstein-Barr virus infection
	Pathways in cancer
	MicroRNAs in cancer
	Colorectal cancer
	Prostate cancer
	Small cell lung cancerhsa04014:Ras signaling pathway
	Jak-STAT signaling pathway
	HTLV-I infection
	Transcriptional misregulation in cancer
	Pancreatic cancer
	Chronic myeloid leukemia
	Small cell lung cancerhsa04151:PI3K-Akt signaling pathway
NetPath Pathway	IL5 Signaling Pathway
	TCR Signaling Pathway
	IL2 Signaling Pathway
	IL3 Signaling Pathway
	Leptin Signaling Pathway
	RANKL Signaling Pathway
	TSLP Signaling PathwayNetPath_14:IL2 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	Notch Signaling PathwayNetPath_11:TCR Signaling Pathway
PANTHER Pathway	Apoptosis signaling pathway
	Oxidative stress response
	CCKR signaling map STP00006:Apoptosis signaling pathway
	CCKR signaling map ST
Pathway Interaction Database	Role of Calcineurin-dependent NFAT signaling in lymphocytes
	IL2-mediated signaling events
	IL2 signaling events mediated by PI3K
	Ceramide signaling pathway
	Direct p53 effectors
	RXR and RAR heterodimerization with other nuclear receptor
	ATF-2 transcription factor network
	C-MYB transcription factor network
	HIV-1 Nef: Negative effector of Fas and TNF-alpha
	Caspase Cascade in Apoptosis
	Signaling events mediated by Stem cell factor receptor (c-Kit)
	EPO signaling pathway
	IL2 signaling events mediated by STAT5
	Validated targets of C-MYC transcriptional repressionil2_pi3kpathway:IL2 signaling events mediated by PI3K
	IL3-mediated signaling events
	IL2 signaling events mediated by STAT5e2f_pathway:E2F transcription factor network
	IL6-mediated signaling events
	HIF-1-alpha transcription factor network
Reactome	Activation of BAD and translocation to mitochondria
	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
	The NLRP1 inflammasomeR-HSA-111453:BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
	The NLRP1 inflammasome
WikiPathways	DNA Damage Response (only ATM dependent)
	Senescence and Autophagy in Cancer
	IL-2 Signaling Pathway
	FAS pathway and Stress induction of HSP regulation
	Focal Adhesion
	Kit receptor signaling pathway
	IL-3 Signaling Pathway
	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
	Apoptosis
	Nanoparticle triggered autophagic cell death
	Amyotrophic lateral sclerosis (ALS)
	Integrated Pancreatic Cancer Pathway
	Corticotropin-releasing hormone
	Interleukin-11 Signaling Pathway
	Prostate Cancer
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in leukocytes - TarBase
	Integrated Breast Cancer Pathway
	Integrated Cancer pathway
	Intrinsic Pathway for Apoptosis
	Apoptosis Modulation and Signaling
	TP53 Network
	Influenza A virus infection
	IL-5 Signaling PathwayWP364:IL-6 signaling pathway
	TNF alpha Signaling Pathway
	IL-7 Signaling Pathway
	Leptin signaling pathway
	Apoptosis Modulation and SignalingWP254:Apoptosis
References
Ref 531104	Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis. Clin Lymphoma Myeloma Leuk. 2010 Aug;10(4):285-9.
Ref 531104	Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis. Clin Lymphoma Myeloma Leuk. 2010 Aug;10(4):285-9.

Drug Information