TTD | Drug: D03BHZ

Drug General Information
Drug ID	D03BHZ
Former ID	DIB007007
Drug Name	AZD8186
Drug Type	Small molecular drug
Indication	Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48]		Phase 1	[524336], [543183]
Company	Astrazeneca
Formula	C24H25F2N3O4
InChI	InChI=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3)9-20-21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3/t14-/m1/s1
InChIKey	LMJFJIDLEAWOQJ-CQSZACIVSA-N
PubChem Compound ID	52913813
Target and Pathway
Target(s)	PI3K beta	Target Info	Inhibitor	[550501]
BioCyc Pathway	Superpathway of inositol phosphate compounds
BioCyc Pathway	3-phosphoinositide biosynthesis
KEGG Pathway	Inositol phosphate metabolism
	ErbB signaling pathway
	Ras signaling pathway
	Rap1 signaling pathway
	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Chemokine signaling pathway
	HIF-1 signaling pathway
	FoxO signaling pathway
	Phosphatidylinositol signaling system
	Sphingolipid signaling pathway
	mTOR signaling pathway
	PI3K-Akt signaling pathway
	AMPK signaling pathway
	Apoptosis
	Adrenergic signaling in cardiomyocytes
	VEGF signaling pathway
	Osteoclast differentiation
	Focal adhesion
	Signaling pathways regulating pluripotency of stem cells
	Platelet activation
	Toll-like receptor signaling pathway
	Jak-STAT signaling pathway
	Natural killer cell mediated cytotoxicity
	T cell receptor signaling pathway
	B cell receptor signaling pathway
	Fc epsilon RI signaling pathway
	Fc gamma R-mediated phagocytosis
	TNF signaling pathway
	Leukocyte transendothelial migration
	Neurotrophin signaling pathway
	Cholinergic synapse
	Inflammatory mediator regulation of TRP channels
	Regulation of actin cytoskeleton
	Insulin signaling pathway
	Progesterone-mediated oocyte maturation
	Estrogen signaling pathway
	Prolactin signaling pathway
	Thyroid hormone signaling pathway
	Oxytocin signaling pathway
	Regulation of lipolysis in adipocytes
	Type II diabetes mellitus
	Non-alcoholic fatty liver disease (NAFLD)
	Aldosterone-regulated sodium reabsorption
	Carbohydrate digestion and absorption
	Bacterial invasion of epithelial cells
	Chagas disease (American trypanosomiasis)
	Toxoplasmosis
	Amoebiasis
	Hepatitis C
	Hepatitis B
	Measles
	Influenza A
	HTLV-I infection
	Epstein-Barr virus infection
	Pathways in cancer
	Viral carcinogenesis
	Proteoglycans in cancer
	Colorectal cancer
	Renal cell carcinoma
	Pancreatic cancer
	Endometrial cancer
	Glioma
	Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
PANTHER Pathway	Angiogenesis
	Apoptosis signaling pathway
	Axon guidance mediated by netrin
	B cell activation
	EGF receptor signaling pathway
	Endothelin signaling pathway
	FGF signaling pathway
	Hypoxia response via HIF activation
	Inflammation mediated by chemokine and cytokine signaling pathway
	Insulin/IGF pathway-protein kinase B signaling cascade
	Integrin signalling pathway
	Interleukin signaling pathway
	PDGF signaling pathway
	PI3 kinase pathway
	T cell activation
	VEGF signaling pathway
	p53 pathway
	Ras Pathway
	p53 pathway feedback loops 2
	CCKR signaling map ST
Pathway Interaction Database	ErbB4 signaling events
	LPA receptor mediated events
	TRAIL signaling pathway
	Signaling events mediated by TCPTP
	FAS (CD95) signaling pathway
	CXCR4-mediated signaling events
	EGF receptor (ErbB1) signaling pathway
	Class I PI3K signaling events
	ErbB1 downstream signaling
	ErbB2/ErbB3 signaling events
	PDGFR-beta signaling pathway
	Nephrin/Neph1 signaling in the kidney podocyte
	Internalization of ErbB1
	CXCR3-mediated signaling events
Reactome	PI3K Cascade
	GPVI-mediated activation cascade
	PIP3 activates AKT signaling
	PI3K/AKT activation
	Role of phospholipids in phagocytosis
	Tie2 Signaling
	Constitutive Signaling by Aberrant PI3K in Cancer
	DAP12 signaling
	Role of LAT2/NTAL/LAB on calcium mobilization
	Nephrin interactions
	G beta:gamma signalling through PI3Kgamma
	VEGFA-VEGFR2 Pathway
	Interleukin-3, 5 and GM-CSF signaling
	Interleukin receptor SHC signaling
	Regulation of signaling by CBL
WikiPathways	Toll-like receptor signaling pathway
	DNA Damage Response (only ATM dependent)
	G13 Signaling Pathway
	Regulation of Actin Cytoskeleton
	Insulin Signaling
	Fc epsilon receptor (FCERI) signaling
	PI Metabolism
	Interleukin-2 signaling
	Fcgamma receptor (FCGR) dependent phagocytosis
	DAP12 interactions
	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
	PIP3 activates AKT signaling
	Signaling Pathways in Glioblastoma
	TCR signaling
	Signaling by PDGF
	Signaling by Insulin receptor
	NGF signalling via TRKA from the plasma membrane
	Nephrin interactions
	Interleukin-3, 5 and GM-CSF signaling
	GPVI-mediated activation cascade
	Cell surface interactions at the vascular wall
	MicroRNAs in cardiomyocyte hypertrophy
	Regulation of toll-like receptor signaling pathway
	AMPK Signaling
References
Ref 524336	ClinicalTrials.gov (NCT01884285) AZD8186 First Time In Patient Ascending Dose Study. U.S. National Institutes of Health.
Ref 543183	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8527).
Ref 550501	National Cancer Institute Drug Dictionary (drug id 751594).

Drug Information