Drug Information

Drug General Information
Drug ID
D03BJF
Former ID
DIB019280
Drug Name
compound 17d
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532095]
Formula
C25H34N6O2
InChI
InChI=1S/C25H34N6O2/c32-24(19-3-1-4-19)27-12-2-11-26-23-22(18-5-6-18)17-28-25(30-23)29-20-7-9-21(10-8-20)31-13-15-33-16-14-31/h7-10,17-19H,1-6,11-16H2,(H,27,32)(H2,26,28,29,30)
InChIKey
CJPMSUUANYLPET-UHFFFAOYSA-N
PubChem Compound ID
44465558
PubChem Substance ID
85745013, 97091160, 140600805, 163332792, 163350924, 238428524, 243098881, 249565876
Target and Pathway
Target(s) MARK3 Target Info Inhibitor [532095]
Inhibitor of nuclear factor kappa-B kinase Target Info Inhibitor [532095]
Mitogen-activated protein kinase kinase kinase 7 Target Info Inhibitor [532095]
TANK-binding kinase 1 Target Info Inhibitor [532095]
NetPath Pathway IL5 Signaling Pathway
FSH Signaling Pathway
PANTHER Pathway TGF-beta signaling pathway
Toll receptor signaling pathway
Wnt signaling pathway
p38 MAPK pathway
Pathway Interaction Database BCR signaling pathway
p38 MAPK signaling pathway
Noncanonical Wnt signaling pathway
Presenilin action in Notch and Wnt signaling
IL1-mediated signaling events
TNF receptor signaling pathway
BMP receptor signaling
JNK signaling in the CD4+ TCR pathway
C-MYB transcription factor network
Ephrin B reverse signaling
TGF-beta receptor signaling
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathwayR-HSA-1169091:Activation of NF-kappaB in B cells
NOD1/2 Signaling Pathway
RIP-mediated NFkB activation via ZBP1
AKT phosphorylates targets in the cytosol
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
Interleukin-1 signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Constitutive Signaling by AKT1 E17K in Cancer
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Negative regulators of RIG-I/MDA5 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulationR-HSA-1169091:Activation of NF-kappaB in B cells
Ca2+ pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TRAF6 mediated induction of TAK1 complex
WikiPathways Toll-like receptor signaling pathway
Estrogen signaling pathway
TCR Signaling Pathway
Insulin Signaling
IL-4 Signaling Pathway
MAPK Signaling Pathway
NLR Proteins
Hair Follicle Development: Induction (Part 1 of 3)
MyD88 cascade initiated on plasma membrane
Cardiac Hypertrophic Response
Cytosolic sensors of pathogen-associated DNA
MyD88 dependent cascade initiated on endosome
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
MyD88:Mal cascade initiated on plasma membrane
Fc epsilon receptor (FCERI) signaling
MyD88-independent cascade
Signaling by the B Cell Receptor (BCR)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Structural Pathway of Interleukin 1 (IL-1)
EBV LMP1 signaling
Polycystic Kidney Disease Pathway
Apoptosis
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
BDNF signaling pathway
Interleukin-11 Signaling Pathway
AGE/RAGE pathway
TNF alpha Signaling Pathway
B Cell Receptor Signaling Pathway
IL17 signaling pathway
TWEAK Signaling Pathway
Leptin signaling pathway
RANKL/RANK Signaling Pathway
Signalling by NGF
IL-1 signaling pathway
TCR signaling
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Interleukin-1 signaling
Apoptosis Modulation and Signaling
Type II diabetes mellitus
MicroRNAs in cardiomyocyte hypertrophy
Regulation of toll-like receptor signaling pathway
Osteopontin Signaling
NOD pathwayWP75:Toll-like receptor signaling pathway
DNA Damage Response (only ATM dependent)
p38 MAPK Signaling Pathway
Wnt Signaling Pathway and Pluripotency
TGF beta Signaling Pathway
IL-6 signaling pathway
FAS pathway and Stress induction of HSP regulation
MAP kinase activation in TLR cascade
References
Ref 532095Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKepsilon kinases. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7169-73.
Ref 532095Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKepsilon kinases. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7169-73.