Drug Information

Drug General Information
Drug ID
D03STO
Former ID
DNC010139
Drug Name
1-benzyl-3,3-diethylazetidine-2,4-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530511]
Formula
C14H17NO2
Canonical SMILES
CCC1(C(=O)N(C1=O)CC2=CC=CC=C2)CC
InChI
1S/C14H17NO2/c1-3-14(4-2)12(16)15(13(14)17)10-11-8-6-5-7-9-11/h5-9H,3-4,10H2,1-2H3
InChIKey
FWKVKYCYDHDEBH-UHFFFAOYSA-N
PubChem Compound ID
24823606
Target and Pathway
Target(s) Leukocyte elastase Target Info Inhibitor [530511]
KEGG Pathway Transcriptional misregulation in cancer
Systemic lupus erythematosus
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor network
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
WikiPathways Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Human Complement System
Degradation of collagen
References
Ref 530511J Med Chem. 2010 Jan 14;53(1):241-53.4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.
Ref 530511J Med Chem. 2010 Jan 14;53(1):241-53.4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.