Drug Information

Drug General Information
Drug ID
D04ILS
Former ID
DNC006422
Drug Name
2-(3-chlorobenzyloxy)-6-chloroisonicotinonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527989]
Formula
C13H8Cl2N2O
Canonical SMILES
C1=CC(=CC(=C1)Cl)COC2=NC(=CC(=C2)C#N)Cl
InChI
1S/C13H8Cl2N2O/c14-11-3-1-2-9(4-11)8-18-13-6-10(7-16)5-12(15)17-13/h1-6H,8H2
InChIKey
MGYAMTJNJZZLMV-UHFFFAOYSA-N
PubChem Compound ID
44409846
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [527989]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 527989Bioorg Med Chem Lett. 2006 Apr 1;16(7):1892-7. Epub 2006 Jan 24.Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists.
Ref 527989Bioorg Med Chem Lett. 2006 Apr 1;16(7):1892-7. Epub 2006 Jan 24.Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists.