Drug Information

Drug General Information
Drug ID
D04JCJ
Former ID
DNC007800
Drug Name
6-(4-(2-(benzylamino)ethyl)phenoxy)picolinamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528996]
Formula
C21H21N3O2
Canonical SMILES
C1=CC=C(C=C1)CNCCC2=CC=C(C=C2)OC3=CC=CC(=N3)C(=O)N
InChI
1S/C21H21N3O2/c22-21(25)19-7-4-8-20(24-19)26-18-11-9-16(10-12-18)13-14-23-15-17-5-2-1-3-6-17/h1-12,23H,13-15H2,(H2,22,25)
InChIKey
JKDWSAGAQLISRL-UHFFFAOYSA-N
PubChem Compound ID
44434931
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Inhibitor [528996]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signaling
References
Ref 528996Bioorg Med Chem Lett. 2007 Oct 1;17(19):5349-52. Epub 2007 Aug 11.Structure-activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1.
Ref 528996Bioorg Med Chem Lett. 2007 Oct 1;17(19):5349-52. Epub 2007 Aug 11.Structure-activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1.