TTD | Drug: D04JJL

Drug General Information
Drug ID	D04JJL
Former ID	DNC011515
Drug Name	N,N'-Bis-(4-ethyl-phenyl)-guanidine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[534685]
Formula	C17H21N3
Canonical SMILES	CCC1=CC=C(C=C1)NC(=NC2=CC=C(C=C2)CC)N
InChI	1S/C17H21N3/c1-3-13-5-9-15(10-6-13)19-17(18)20-16-11-7-14(4-2)8-12-16/h5-12H,3-4H2,1-2H3,(H3,18,19,20)
InChIKey	DXGARAMIKHFTJV-UHFFFAOYSA-N
PubChem Compound ID	14771671
Target and Pathway
Target(s)	Glutamate [NMDA] receptor subunit epsilon 1	Target Info	Inhibitor	[534685]
	Glutamate [NMDA] receptor subunit epsilon 2	Target Info	Inhibitor	[534685]
	NMDA receptor subunit NR1	Target Info	Inhibitor	[534685]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Circadian entrainment
	Long-term potentiation
	Glutamatergic synapse
	Dopaminergic synapse
	Alzheimer's disease
	Amyotrophic lateral sclerosis (ALS)
	Cocaine addiction
	Amphetamine addiction
	Nicotine addiction
	Alcoholism
	Systemic lupus erythematosushsa04014:Ras signaling pathway
	Huntington's disease
PANTHER Pathway	Huntington disease
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database	Reelin signaling pathwayerbb4_pathway:ErbB4 signaling events
Pathway Interaction Database	Reelin signaling pathway
Reactome	Unblocking of NMDA receptor, glutamate binding and activation
	CREB phosphorylation through the activation of CaMKII
	Ras activation uopn Ca2+ infux through NMDA receptor
	RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
	RAF/MAP kinase cascade
WikiPathways	Hypothetical Network for Drug Addiction
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
	BDNF signaling pathwayWP706:SIDS Susceptibility Pathways
	Spinal Cord Injury
	BDNF signaling pathway
	Alzheimers Disease
References
Ref 534685	J Med Chem. 1998 Aug 13;41(17):3298-302.Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents.
Ref 534685	J Med Chem. 1998 Aug 13;41(17):3298-302.Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents.

Drug Information