Drug Information

Drug General Information
Drug ID
D04UWG
Former ID
DIB008757
Drug Name
Autologous T-cell therapy
Synonyms
Anti-PSMA designer T cells, Roger Williams; Gene therapy (chimeric anti-PSMA antibody-TCR), Roger Williams; Autologous T-cell therapy (anti-PSMA-CD3, prostate cancer); Autologous T-cell therapy (anti-PSMA-CD3, prostate cancer), Roger Williams Medical Center; Retrovirus-based ex vivo gene therapy (anti-PSMA-CD3, prostate cancer), Roger Williams Medical Center
Drug Type
Antibody
Indication Prostate cancer [ICD9: 185; ICD10:C61] Phase 1 [525412]
Company
Roger Williams Medical Center
Target and Pathway
Target(s) CD3 Target Info [532162]
T-cell surface glycoprotein CD3 epsilon chain Target Info [532162]
Glutamate carboxypeptidase II Target Info [532162]
KEGG Pathway Hematopoietic cell lineage
T cell receptor signaling pathway
Chagas disease (American trypanosomiasis)
Measles
HTLV-I infectionhsa04640:Hematopoietic cell lineage
HTLV-I infection
Primary immunodeficiencyhsa00250:Alanine, aspartate and glutamate metabolism
Metabolic pathways
Vitamin digestion and absorption
NetPath Pathway TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
Leptin Signaling PathwayNetPath_11:TCR Signaling Pathway
TNFalpha Signaling Pathway
PANTHER Pathway T cell activationP00053:T cell activation
Pathway Interaction Database TCR signaling in na&#xef
IL12-mediated signaling events
TCR signaling in na&#xef
CXCR4-mediated signaling events
Downstream signaling in na&#xef
IL12 signaling mediated by STAT4tcr_pathway:TCR signaling in na&#xef
IL23-mediated signaling events
IL12 signaling mediated by STAT4
Reactome Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
PD-1 signalingR-HSA-198933:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
PD-1 signalingR-HSA-70614:Amino acid synthesis and interconversion (transamination)
WikiPathways TCR Signaling Pathway
Fcgamma receptor (FCGR) dependent phagocytosis
TCR signaling
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Costimulation by the CD28 familyWP69:TCR Signaling Pathway
Costimulation by the CD28 familyWP241:One Carbon Metabolism
References
Ref 525412Clinical application of genetically modified T cells in cancer therapy. Clin Transl Immunology. 2014 May 16;3(5):e16. doi: 10.1038/cti.2014.7. eCollection 2014.
Ref 532162Antitumor activities of PSMA?CD3 diabodies by redirected T-cell lysis of prostate cancer cells. Immunotherapy. 2013 Jan;5(1):27-38.