TTD | Drug: D05FFT

Drug General Information
Drug ID	D05FFT
Former ID	DIB019804
Drug Name	HDS-029
Synonyms	HDS 029
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541244]
Formula	C17H11ClFN5O
InChI	InChI=1S/C17H11ClFN5O/c1-2-3-16(25)24-15-7-11-14(8-20-15)21-9-22-17(11)23-10-4-5-13(19)12(18)6-10/h4-9H,1H3,(H,20,24,25)(H,21,22,23)
InChIKey	DLPSDPPZXRJQOY-UHFFFAOYSA-N
PubChem Compound ID	11566580
PubChem Substance ID	16668860, 23685192, 26758662, 42708458, 50112948, 53800786, 74799426, 99302673, 99431515, 103480257, 104067356, 135698682, 163121902, 163688179, 175607405, 178102588, 179694489, 204371493, 208264996, 226589680, 241376051, 249262313, 249617646, 252156680
Target and Pathway
Target(s)	Receptor protein-tyrosine kinase erbB-4	Target Info	Inhibitor	[528037]
	mRNA of HER2	Target Info	Inhibitor	[528037]
	Epidermal growth factor receptor	Target Info	Inhibitor	[528037]
KEGG Pathway	ErbB signaling pathway
	Calcium signaling pathway
	Endocytosis
	Proteoglycans in cancerhsa04012:ErbB signaling pathway
	HIF-1 signaling pathway
	Focal adhesion
	Adherens junction
	Pathways in cancer
	Proteoglycans in cancer
	MicroRNAs in cancer
	Pancreatic cancer
	Endometrial cancer
	Prostate cancer
	Bladder cancer
	Non-small cell lung cancer
	Central carbon metabolism in cancerhsa04010:MAPK signaling pathway
	Ras signaling pathway
	Rap1 signaling pathway
	Cytokine-cytokine receptor interaction
	FoxO signaling pathway
	PI3K-Akt signaling pathway
	Dorso-ventral axis formation
	Gap junction
	Regulation of actin cytoskeleton
	GnRH signaling pathway
	Estrogen signaling pathway
	Oxytocin signaling pathway
	Epithelial cell signaling in Helicobacter pylori infection
	Hepatitis C
	Glioma
	Melanoma
	Central carbon metabolism in cancer
	Choline metabolism in cancer
NetPath Pathway	TCR Signaling PathwayNetPath_16:IL4 Signaling Pathway
NetPath Pathway	EGFR1 Signaling Pathway
PANTHER Pathway	Alzheimer disease-presenilin pathway
	Cadherin signaling pathway
	EGF receptor signaling pathwayP00012:Cadherin signaling pathway
	EGF receptor signaling pathway
Pathway Interaction Database	ErbB4 signaling events
	ErbB2/ErbB3 signaling events
	ErbB receptor signaling network
	a6b1 and a6b4 Integrin signaling
	Validated targets of C-MYC transcriptional repressionlysophospholipid_pathway:LPA receptor mediated events
	Signaling events mediated by PTP1B
	Arf6 signaling events
	Signaling events mediated by TCPTP
	Thromboxane A2 receptor signaling
	SHP2 signaling
	Regulation of Telomerase
	EGF receptor (ErbB1) signaling pathway
	EGFR-dependent Endothelin signaling events
	Posttranslational regulation of adherens junction stability and dissassembly
	Direct p53 effectors
	ErbB1 downstream signaling
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	E-cadherin signaling in keratinocytes
	Internalization of ErbB1
	Stabilization and expansion of the E-cadherin adherens junction
	Syndecan-3-mediated signaling events
PathWhiz Pathway	Phosphatidylinositol Phosphate Metabolism
Reactome	SHC1 events in ERBB2 signaling
	PLCG1 events in ERBB2 signaling
	PIP3 activates AKT signaling
	GRB2 events in ERBB2 signaling
	PI3K events in ERBB2 signaling
	Constitutive Signaling by Aberrant PI3K in Cancer
	Sema4D induced cell migration and growth-cone collapse
	RAF/MAP kinase cascadeR-HSA-1236382:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
	GRB2 events in EGFR signaling
	GAB1 signalosome
	SHC1 events in EGFR signaling
	EGFR downregulation
	EGFR Transactivation by Gastrin
	Constitutive Signaling by EGFRvIII
	RAF/MAP kinase cascade
WikiPathways	ErbB Signaling Pathway
	EV release from cardiac cells and their functional effectsWP710:DNA Damage Response (only ATM dependent)
	EGF/EGFR Signaling Pathway
	Extracellular vesicle-mediated signaling in recipient cells
	Bladder Cancer
	Signaling by ERBB2
	Integrated Pancreatic Cancer Pathway
	Signaling Pathways in Glioblastoma
	Leptin signaling pathway
	miR-targeted genes in muscle cell - TarBase
	Semaphorin interactionsWP673:ErbB Signaling Pathway
	Regulation of Actin Cytoskeleton
	MAPK Signaling Pathway
	Focal Adhesion
	Aryl Hydrocarbon Receptor Pathway
	TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
	Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
	Hair Follicle Development: Induction (Part 1 of 3)
	Signaling by ERBB4
	Gastrin-CREB signalling pathway via PKC and MAPK
	PIP3 activates AKT signaling
	Nanoparticle-mediated activation of receptor signaling
	Aryl Hydrocarbon Receptor
	Spinal Cord Injury
	Gastric cancer network 2
	AGE/RAGE pathway
	Arylhydrocarbon receptor (AhR) signaling pathway
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in epithelium - TarBase
	Integrated Breast Cancer Pathway
	Signaling by EGFR
	L1CAM interactions
References
Ref 541244	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5965).
Ref 528037	J Med Chem. 2006 Feb 23;49(4):1475-85.Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors.

Drug Information