TTD | Drug: D05IRT

Drug General Information
Drug ID	D05IRT
Former ID	DCL001074
Drug Name	P276-00
Drug Type	Small molecular drug
Indication	Mantle cell lymphoma [ICD9: 200.4, 202.8, 203.0, 208.9; ICD10:C81-C86, C85.7, C90.0, C91-C95]		Phase 2	[533193]
Company	Nicholas Piramal
Formula	C21H21NO5
Canonical SMILES	CN1CCC(C1CO)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4)O)O
InChI	1S/C21H21NO5/c1-22-8-7-13(14(22)11-23)19-15(24)9-16(25)20-17(26)10-18(27-21(19)20)12-5-3-2-4-6-12/h2-6,9-10,13-14,23-25H,7-8,11H2,1H3
InChIKey	HRTOUPQLDWWXIX-UHFFFAOYSA-N
PubChem Compound ID	10406644
PubChem Substance ID	15424032, 22753724, 42236723, 78680062, 134339470, 164147479, 227416382
Target and Pathway
Target(s)	Cell division protein kinase 9	Target Info	Inhibitor	[537564]
	Cell division control protein 2 homolog	Target Info	Inhibitor	[537564]
	Cell division protein kinase 4	Target Info	Inhibitor	[537564]
KEGG Pathway	Transcriptional misregulation in cancerhsa04110:Cell cycle
	Oocyte meiosis
	p53 signaling pathway
	Gap junction
	Progesterone-mediated oocyte maturation
	Herpes simplex infection
	Epstein-Barr virus infection
	Viral carcinogenesishsa04110:Cell cycle
	PI3K-Akt signaling pathway
	Tight junction
	T cell receptor signaling pathway
	Hepatitis B
	Measles
	HTLV-I infection
	Pathways in cancer
	Viral carcinogenesis
	Pancreatic cancer
	Glioma
	Melanoma
	Bladder cancer
	Chronic myeloid leukemia
	Small cell lung cancer
	Non-small cell lung cancer
NetPath Pathway	EGFR1 Signaling PathwayNetPath_21:RANKL Signaling PathwayNetPath_11:TCR Signaling Pathway
	EGFR1 Signaling Pathway
	RANKL Signaling Pathway
Pathway Interaction Database	p73 transcription factor network
	E2F transcription factor network
	PLK1 signaling events
	AP-1 transcription factor network
	FOXM1 transcription factor network
	Retinoic acid receptors-mediated signalingsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
	Validated targets of C-MYC transcriptional activation
	ATF-2 transcription factor network
	Regulation of retinoblastoma protein
Reactome	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionR-HSA-110056:MAPK3 (ERK1) activation
	E2F mediated regulation of DNA replication
	G0 and Early G1
	Cyclin B2 mediated events
	Golgi Cisternae Pericentriolar Stack Reorganization
	Cdc20:Phospho-APC/C mediated degradation of Cyclin A
	Regulation of APC/C activators between G1/S and early anaphase
	Phosphorylation of the APC/C
	Phosphorylation of Emi1
	Condensation of Prophase Chromosomes
	MASTL Facilitates Mitotic Progression
	Resolution of Sister Chromatid Cohesion
	Condensation of Prometaphase Chromosomes
	Regulation of PLK1 Activity at G2/M Transition
	Activation of NIMA Kinases NEK9, NEK6, NEK7
	Loss of Nlp from mitotic centrosomes
	Recruitment of mitotic centrosome proteins and complexes
	Loss of proteins required for interphase microtubule organization?from the centrosome
	Recruitment of NuMA to mitotic centrosomes
	Depolymerisation of the Nuclear Lamina
	Anchoring of the basal body to the plasma membrane
	MAPK6/MAPK4 signaling
	G1/S-Specific Transcription
	Cyclin A/B1 associated events during G2/M transition
	G2/M DNA replication checkpoint
	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-2559580:Oxidative Stress Induced Senescence
	Senescence-Associated Secretory Phenotype (SASP)
	Oncogene Induced Senescence
	RMTs methylate histone arginines
	Transcriptional regulation of white adipocyte differentiation
	Ubiquitin-dependent degradation of Cyclin D1
	Cyclin D associated events in G1
	Meiotic recombination
WikiPathways	Cardiac Hypertrophic Response
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Host Interactions of HIV factors
	HIV Life Cycle
	IL-9 Signaling Pathway
	RNA Polymerase II Transcription
	MicroRNAs in cardiomyocyte hypertrophyWP707:DNA Damage Response
	G1 to S cell cycle control
	TGF beta Signaling Pathway
	PPAR Alpha Pathway
	MAP kinase activation in TLR cascade
	RAF/MAP kinase cascade
	Mitotic Prophase
	Mitotic Prometaphase
	BMI1
	ATM Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Spinal Cord Injury
	Prostate Cancer
	Regulation of Microtubule Cytoskeleton
	Integrated Cancer pathway
	Mitotic G2-G2/M phases
	Mitotic G1-G1/S phases
	Cell Cycle
	APC/C-mediated degradation of cell cycle proteins
	Cell Cycle Checkpoints
	miRNA Regulation of DNA Damage ResponseWP707:DNA Damage Response
	Ovarian Infertility Genes
	Bladder Cancer
	S Phase
	Transcriptional Regulation of White Adipocyte Differentiation
	Meiotic Recombination
	Integrated Pancreatic Cancer Pathway
	Signaling Pathways in Glioblastoma
	TSH signaling pathway
	Integrated Breast Cancer Pathway
	miRNA Regulation of DNA Damage Response
References
Ref 533193	A phase II, single-arm, open-label, multicenter study to evaluate the efficacy and safety of P276-00, a cyclin-dependent kinase inhibitor, in patients with relapsed or refractory mantle cell lymphoma. Clin Lymphoma Myeloma Leuk. 2015 Jul;15(7):392-7.
Ref 537564	Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66.

Drug Information