Drug Information

Drug General Information
Drug ID
D05KHN
Former ID
DIB006492
Drug Name
ICI-169369
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Terminated [539780], [544709]
Company
Zeneca Group plc
Formula
C19H20N2S
InChI
InChI=1S/C19H20N2S/c1-21(2)12-13-22-19-17(15-8-4-3-5-9-15)14-16-10-6-7-11-18(16)20-19/h3-11,14H,12-13H2,1-2H3
InChIKey
HYOLQGVNMQNERE-UHFFFAOYSA-N
CAS Number
CAS 85273-96-7
PubChem Compound ID
122265
PubChem Substance ID
10240001, 15048696, 29302679, 47359944, 47657141, 50070417, 50071058, 57340048, 77509253, 85209761, 103836502, 104415417, 117401684, 126435013, 128131790, 135077821, 135650368, 136351045, 162661470, 164339274, 172869264, 179293644, 228731737, 241149551, 242103099
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Modulator
5-hydroxytryptamine 2C receptor Target Info Modulator
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
References
Ref 539780(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 273).
Ref 544709Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000690)