Drug Information

Drug General Information
Drug ID
D05OAE
Former ID
DNC014881
Drug Name
(12E,20Z,18S)-8-hydroxyvariabilin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540667]
Formula
C25H36O5
InChI
InChI=1S/C25H36O5/c1-18(8-5-9-19(2)16-22-23(26)20(3)24(27)30-22)10-6-13-25(4,28)14-7-11-21-12-15-29-17-21/h10,12,15-17,19,26,28H,5-9,11,13-14H2,1-4H3/b18-10+,22-16-/t19-,25?/m0/s1
InChIKey
QFBUNOKEKXMSCV-UYYPKTQPSA-N
PubChem Compound ID
54726845
PubChem Substance ID
103600709, 134352086, 178100895
Target and Pathway
Target(s) Glycine receptor Target Info Inhibitor [530814]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Ligand-gated ion channel transport
WikiPathways Iron uptake and transport
References
Ref 540667(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4072).
Ref 530814Bioorg Med Chem. 2010 Apr 15;18(8):2912-9. Epub 2010 Mar 6.Ircinialactams: subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae.