Drug Information

Drug General Information
Drug ID
D06QGJ
Former ID
DNC011214
Drug Name
3-(1-benzylpiperidin-4-yloxy)benzamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531117]
Formula
C19H22N2O2
Canonical SMILES
C1CN(CCC1OC2=CC=CC(=C2)C(=O)N)CC3=CC=CC=C3
InChI
1S/C19H22N2O2/c20-19(22)16-7-4-8-18(13-16)23-17-9-11-21(12-10-17)14-15-5-2-1-3-6-15/h1-8,13,17H,9-12,14H2,(H2,20,22)
InChIKey
IDSIUINGWBNUFD-UHFFFAOYSA-N
PubChem Compound ID
52946209
Target and Pathway
Target(s) Kappa-type opioid receptor Target Info Inhibitor [531117]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Opioid prodynorphin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 531117Bioorg Med Chem Lett. 2010 Oct 1;20(19):5847-52. Epub 2010 Jul 30.Discovery of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as selective antagonists of the kappa opioid receptor. Part 1.
Ref 531117Bioorg Med Chem Lett. 2010 Oct 1;20(19):5847-52. Epub 2010 Jul 30.Discovery of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as selective antagonists of the kappa opioid receptor. Part 1.