Drug Information

Drug General Information
Drug ID
D06REJ
Former ID
DIB015221
Drug Name
MX-7065
Synonyms
Cdc25 phosphatase inhibitors, Maxia Pharmaceuticals; MX-7065; MX-7102; MX-7174; MX-7214; MX-7306
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Terminated [547465]
Company
Maxia Pharmaceuticals Inc
Target and Pathway
Target(s) M-phase inducer phosphatase 3 Target Info Inhibitor [551830]
M-phase inducer phosphatase 1 Target Info Inhibitor [551830]
M-phase inducer phosphatase 2 Target Info Inhibitor [551830]
KEGG Pathway Cell cycle
Oocyte meiosis
Progesterone-mediated oocyte maturation
MicroRNAs in cancerhsa04110:Cell cycle
MicroRNAs in cancerhsa04010:MAPK signaling pathway
MicroRNAs in cancer
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_14:IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Wnt Signaling Pathway
PANTHER Pathway p53 pathway
Pathway Interaction Database ATR signaling pathway
ATM pathway
PLK1 signaling events
PLK3 signaling eventse2f_pathway:E2F transcription factor network
Validated targets of C-MYC transcriptional activation
ATM pathwayplk1_pathway:PLK1 signaling events
FOXM1 transcription factor network
p38 signaling mediated by MAPKAP kinases
Aurora A signaling
Reactome Polo-like kinase mediated events
Cyclin B2 mediated events
Activation of ATR in response to replication stress
RHO GTPases activate PKNs
Cyclin A/B1 associated events during G2/M transition
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-113510:E2F mediated regulation of DNA replication
G0 and Early G1
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Cyclin A:Cdk2-associated events at S phase entryR-HSA-157881:Cyclin B2 mediated events
Cyclin A:Cdk2-associated events at S phase entry
WikiPathways Monoamine Transport
DNA Damage Response
ATM Signaling Pathway
Integrated Pancreatic Cancer Pathway
Mitotic G2-G2/M phases
Cell Cycle
Cell Cycle Checkpoints
miRNA Regulation of DNA Damage ResponseWP707:DNA Damage Response
G1 to S cell cycle control
S Phase
Retinoblastoma (RB) in Cancer
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Mitotic G1-G1/S phases
miRNAs involved in DNA damage response
miRNA Regulation of DNA Damage ResponseWP615:Senescence and Autophagy in Cancer
MAPK Signaling Pathway
References
Ref 547465Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016615)
Ref 551830Handbook of Assay Development in Drug Discovery, Lisa K. Minor, 2013. Page(11).