TTD | Drug: D07AEC

Drug General Information
Drug ID	D07AEC
Former ID	DNC010616
Drug Name	RESCOVITINE
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530612]
Formula	C19H28N6O
Canonical SMILES	CCC(CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)NCN2C(C)C
InChI	1S/C19H28N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,13,15,21,26H,4,10-12H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
InChIKey	RMSINZVFNDWCCK-OAHLLOKOSA-N
PubChem Compound ID	46881287
Target and Pathway
Target(s)	Cyclin-A2	Target Info	Inhibitor	[530612]
Target(s)	Cell division protein kinase 2	Target Info	Inhibitor	[530612]
KEGG Pathway	DNA replication
	Base excision repair
	Nucleotide excision repair
	Mismatch repair
	Cell cycle
	Hepatitis B
	HTLV-I infectionhsa04068:FoxO signaling pathway
	Oocyte meiosis
	p53 signaling pathway
	PI3K-Akt signaling pathway
	Progesterone-mediated oocyte maturation
	Measles
	Herpes simplex infection
	Epstein-Barr virus infection
	Pathways in cancer
	Viral carcinogenesis
	Prostate cancer
	Small cell lung cancer
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	p53 pathway
PANTHER Pathway	p53 pathway feedback loops 2
Pathway Interaction Database	Regulation of nuclear SMAD2/3 signaling
	Signaling events mediated by PRL
	p73 transcription factor network
	E2F transcription factor network
	ATR signaling pathway
	mTOR signaling pathway
	IL2-mediated signaling events
	FoxO family signaling
	FOXM1 transcription factor network
	BARD1 signaling events
	p53 pathway
	Regulation of retinoblastoma protein
PathWhiz Pathway	Nucleotide Excision Repair
Reactome	E2F mediated regulation of DNA replication
	G0 and Early G1
	Cdc20:Phospho-APC/C mediated degradation of Cyclin A
	Regulation of APC/C activators between G1/S and early anaphase
	SCF(Skp2)-mediated degradation of p27/p21
	Senescence-Associated Secretory Phenotype (SASP)
	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
	HDR through Homologous Recombination (HRR)
	Processing of DNA double-strand break ends
	Dual Incision in GG-NER
	Dual incision in TC-NER
	Gap-filling DNA repair synthesis and ligation in TC-NER
	G2 Phase
	Orc1 removal from chromatin
	G1/S-Specific Transcription
	Cyclin A/B1 associated events during G2/M transition
	Cyclin A:Cdk2-associated events at S phase entryR-HSA-1538133:G0 and Early G1
	Activation of ATR in response to replication stress
	DNA Damage/Telomere Stress Induced Senescence
	Cyclin E associated events during G1/S transition
	p53-Dependent G1 DNA Damage Response
	Cyclin A:Cdk2-associated events at S phase entry
	Meiotic recombination
	Factors involved in megakaryocyte development and platelet production
WikiPathways	Senescence and Autophagy in Cancer
	Mismatch repair
	DNA Replication
	G1 to S cell cycle control
	EGF/EGFR Signaling Pathway
	S Phase
	Nifedipine Activity
	Primary Focal Segmental Glomerulosclerosis FSGS
	Retinoblastoma (RB) in Cancer
	Integrated Pancreatic Cancer Pathway
	Nucleotide Excision Repair
	Telomere Maintenance
	Synthesis of DNA
	Mitotic G1-G1/S phases
	Cell Cycle
	Base Excision RepairWP707:DNA Damage Response
	ID signaling pathway
	M/G1 Transition
	Meiotic Recombination
	Aryl Hydrocarbon Receptor
	ATM Signaling Pathway
	Spinal Cord Injury
	Oncostatin M Signaling Pathway
	Prostate Cancer
	Signaling Pathways in Glioblastoma
	TSH signaling pathway
	Integrated Breast Cancer Pathway
	Integrated Cancer pathway
	Regulation of DNA replication
	Mitotic G2-G2/M phases
	Factors involved in megakaryocyte development and platelet production
	APC/C-mediated degradation of cell cycle proteins
	Cell Cycle Checkpoints
	miRNA Regulation of DNA Damage Response
References
Ref 530612	Eur J Med Chem. 2010 Mar;45(3):1158-66. Epub 2009 Dec 21.Design, synthesis, and biological evaluation of novel pyrimidine derivatives as CDK2 inhibitors.
Ref 530612	Eur J Med Chem. 2010 Mar;45(3):1158-66. Epub 2009 Dec 21.Design, synthesis, and biological evaluation of novel pyrimidine derivatives as CDK2 inhibitors.

Drug Information