TTD | Drug: D07IEU

Drug General Information
Drug ID	D07IEU
Former ID	DNCL002316
Drug Name	MLN2480
Drug Type	Small molecular drug
Indication	Melanoma [ICD9: 172; ICD10:C43]		Phase 1	[523603]
Company	Millennium Pharmaceuticals
Formula	C17H12Cl2F3N7O2S
Canonical SMILES	CC(C1=NC=C(S1)C(=O)NC2=NC=C(C(=C2)C(F)(F)F)Cl)NC(=O)C3=<br />C(C(=NC=N3)N)Cl
InChI	1S/C17H12Cl2F3N7O2S/c1-6(28-15(31)12-11(19)13(23)27-5-26-12)16-25-4-9(32-16)14(30)29-10-2-7(17(20,21)22)8(18)3-24-10/h2-6H,1H3,(H,28,31)(H2,23,26,27)(H,24,29,30)/t6-/m1/s1
InChIKey	VWMJHAFYPMOMGF-ZCFIWIBFSA-N
PubChem Compound ID	25161177
PubChem Substance ID	57255246, 85010832, 137367273, 152258657, 160647493, 163643159, 174006384, 184816343, 198960773, 230156499, 242591772, 243631005, 252476758
Target and Pathway
Target(s)	mRNA of RAF proto-oncogene serine/threonine-protein kinase	Target Info	Inhibitor	[550478]
BioCyc Pathway	MAP kinase cascade
KEGG Pathway	MAPK signaling pathway
	ErbB signaling pathway
	Ras signaling pathway
	Rap1 signaling pathway
	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Chemokine signaling pathway
	FoxO signaling pathway
	Sphingolipid signaling pathway
	PI3K-Akt signaling pathway
	Vascular smooth muscle contraction
	VEGF signaling pathway
	Focal adhesion
	Gap junction
	Signaling pathways regulating pluripotency of stem cells
	Natural killer cell mediated cytotoxicity
	T cell receptor signaling pathway
	B cell receptor signaling pathway
	Fc epsilon RI signaling pathway
	Fc gamma R-mediated phagocytosis
	Long-term potentiation
	Neurotrophin signaling pathway
	Serotonergic synapse
	Long-term depression
	Regulation of actin cytoskeleton
	Insulin signaling pathway
	GnRH signaling pathway
	Progesterone-mediated oocyte maturation
	Estrogen signaling pathway
	Melanogenesis
	Prolactin signaling pathway
	Thyroid hormone signaling pathway
	Oxytocin signaling pathway
	Alcoholism
	Tuberculosis
	Hepatitis C
	Hepatitis B
	Influenza A
	Pathways in cancer
	Proteoglycans in cancer
	MicroRNAs in cancer
	Colorectal cancer
	Renal cell carcinoma
	Pancreatic cancer
	Endometrial cancer
	Glioma
	Prostate cancer
	Melanoma
	Bladder cancer
	Chronic myeloid leukemia
	Acute myeloid leukemia
	Non-small cell lung cancer
	Central carbon metabolism in cancer
	Choline metabolism in cancer
NetPath Pathway	IL5 Signaling Pathway
	IL2 Signaling Pathway
	EGFR1 Signaling Pathway
PANTHER Pathway	Angiogenesis
	B cell activation
	EGF receptor signaling pathway
	Endothelin signaling pathway
	FGF signaling pathway
	Inflammation mediated by chemokine and cytokine signaling pathway
	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
	Integrin signalling pathway
	Interleukin signaling pathway
	PDGF signaling pathway
	T cell activation
	VEGF signaling pathway
	Ras Pathway
	Angiotensin II-stimulated signaling through G proteins and beta-arrestin
	CCKR signaling map ST
Pathway Interaction Database	Fc-epsilon receptor I signaling in mast cells
	Endothelins
	BCR signaling pathway
	GMCSF-mediated signaling events
	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
	CDC42 signaling events
	SHP2 signaling
	mTOR signaling pathway
	IL2-mediated signaling events
	IGF1 pathway
	Ras signaling in the CD4+ TCR pathway
	Ceramide signaling pathway
	ErbB1 downstream signaling
	ErbB2/ErbB3 signaling events
	PDGFR-beta signaling pathway
	p38 signaling mediated by MAPKAP kinases
	Nongenotropic Androgen signaling
	Internalization of ErbB1
	CXCR3-mediated signaling events
	Signaling events mediated by Stem cell factor receptor (c-Kit)
	Signaling events mediated by VEGFR1 and VEGFR2
	Class I PI3K signaling events mediated by Akt
	Trk receptor signaling mediated by the MAPK pathway
	Downstream signaling in na&#xef
	Regulation of retinoblastoma protein
	Signaling events mediated by focal adhesion kinase
PathWhiz Pathway	Fc Epsilon Receptor I Signaling in Mast Cells
PathWhiz Pathway	Insulin Signalling
Reactome	Stimuli-sensing channels
	GP1b-IX-V activation signalling
	CREB phosphorylation through the activation of Ras
	CD209 (DC-SIGN) signaling
	RAF activation
	MAP2K and MAPK activation
	Negative feedback regulation of MAPK pathway
	Negative regulation of MAPK pathway
WikiPathways	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	TCR Signaling Pathway
	Senescence and Autophagy in Cancer
	EPO Receptor Signaling
	Regulation of Actin Cytoskeleton
	IL-2 Signaling Pathway
	Insulin Signaling
	EGF/EGFR Signaling Pathway
	MAPK Cascade
	MAPK Signaling Pathway
	TGF beta Signaling Pathway
	Signaling of Hepatocyte Growth Factor Receptor
	Kit receptor signaling pathway
	Extracellular vesicle-mediated signaling in recipient cells
	IL-3 Signaling Pathway
	Cardiac Hypertrophic Response
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	RAF/MAP kinase cascade
	Iron uptake and transport
	Nanoparticle-mediated activation of receptor signaling
	PDGF Pathway
	Retinoblastoma (RB) in Cancer
	BDNF signaling pathway
	Integrated Pancreatic Cancer Pathway
	Oncostatin M Signaling Pathway
	Corticotropin-releasing hormone
	Interleukin-11 Signaling Pathway
	AGE/RAGE pathway
	TNF alpha Signaling Pathway
	B Cell Receptor Signaling Pathway
	Prostate Cancer
	Signaling Pathways in Glioblastoma
	Endothelin Pathways
	TWEAK Signaling Pathway
	FSH signaling pathway
	Leptin signaling pathway
	Rap1 signalling
	Integrin-mediated Cell Adhesion
	GP1b-IX-V activation signalling
	MicroRNAs in cardiomyocyte hypertrophy
	IL-5 Signaling Pathway
References
Ref 523603	ClinicalTrials.gov (NCT01425008) Study of MLN2480 in Patients With Relapsed or Refractory Solid Tumors Followed by a Dose Expansion in Patients With Metastatic Melanoma. U.S. National Institutes of Health.
Ref 550478	National Cancer Institute Drug Dictionary (drug id 710688).

Drug Information