Drug General Information
Drug ID
D07IQR
Former ID
DNC006104
Drug Name
3-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527996]
Formula
C20H18N4O3
Canonical SMILES
C1=CC=C(C=C1)COC2=C(N=CC=C2)NC(=O)NC3=CC=CC(=C3)C(=O)N
InChI
1S/C20H18N4O3/c21-18(25)15-8-4-9-16(12-15)23-20(26)24-19-17(10-5-11-22-19)27-13-14-6-2-1-3-7-14/h1-12H,13H2,(H2,21,25)(H2,22,23,24,26)
InChIKey
RLBJUMUHKDTSCO-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Peptidyl-prolyl cis-trans isomerase A Target Info Inhibitor [527996]
Reactome Platelet degranulation
Uncoating of the HIV Virion
Budding and maturation of HIV virion
Integration of provirus
Early Phase of HIV Life Cycle
Minus-strand DNA synthesis
Plus-strand DNA synthesis
Binding and entry of HIV virion
Assembly Of The HIV Virion
APOBEC3G mediated resistance to HIV-1 infection
Basigin interactions
WikiPathways Signaling by the B Cell Receptor (BCR)
Host Interactions of HIV factors
HIV Life Cycle
JAK/STAT
Cell surface interactions at the vascular wall
References
Ref 527996J Med Chem. 2006 Feb 9;49(3):900-10.Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
Ref 527996J Med Chem. 2006 Feb 9;49(3):900-10.Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.