Drug Information

Drug General Information
Drug ID
D07LCC
Former ID
DNC012431
Drug Name
4-Methoxymethyl-3,6-dipropoxy-9H-beta-carboline
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534660]
Formula
C19H24N2O3
Canonical SMILES
CCCOC1=CC2=C(C=C1)NC3=CN=C(C(=C23)COC)OCCC
InChI
1S/C19H24N2O3/c1-4-8-23-13-6-7-16-14(10-13)18-15(12-22-3)19(24-9-5-2)20-11-17(18)21-16/h6-7,10-11,21H,4-5,8-9,12H2,1-3H3
InChIKey
BTCRVOSPHNKQGJ-UHFFFAOYSA-N
PubChem Compound ID
10711377
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor Target Info Inhibitor [534660]
Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [534660]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 534660J Med Chem. 1998 Jul 2;41(14):2537-52.Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423) at wild type and recombinant GABAA receptors.
Ref 534660J Med Chem. 1998 Jul 2;41(14):2537-52.Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423) at wild type and recombinant GABAA receptors.