Drug Information

Drug General Information
Drug ID
D07WQA
Former ID
DNC002701
Drug Name
Naphthalene Trisulfonate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551393]
Formula
C10H8O9S3
Canonical SMILES
C1=CC2=C(C=C(C=C2C=C1S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O
InChI
1S/C10H8O9S3/c11-20(12,13)7-1-2-9-6(3-7)4-8(21(14,15)16)5-10(9)22(17,18)19/h1-5H,(H,11,12,13)(H,14,15,16)(H,17,18,19)
InChIKey
ZPBSAMLXSQCSOX-UHFFFAOYSA-N
PubChem Compound ID
4438
PubChem Substance ID
3140669, 4353749, 8147359, 8152739, 14755186, 26710779, 29223535, 32314241, 74626995, 92716498, 93304418, 103093260, 103157917, 103760203, 104306409, 117632940, 118696716, 125722702, 126654360, 127988999, 128141516, 129466586, 129842179, 129934532, 135025411, 136226394, 137051035, 143857351, 152103602, 162634189, 163414350, 172908300, 176322721, 184534494, 223538148, 224842934, 226645038, 241162123, 249557725, 252478574
Target and Pathway
Target(s) Heparin-binding growth factor1 Target Info Inhibitor [551393]
KEGG Pathway MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
PI3K-Akt signaling pathway
Hippo signaling pathway
Regulation of actin cytoskeleton
Pathways in cancer
Melanoma
PANTHER Pathway Angiogenesis
FGF signaling pathway
Pathway Interaction Database FGF signaling pathway
Reactome PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
FGFR3c ligand binding and activation
FGFR2c ligand binding and activation
FGFR2b ligand binding and activation
FGFR3 mutant receptor activation
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade
Phospholipase C-mediated cascade
Phospholipase C-mediated cascade
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RAF/MAP kinase cascade
WikiPathways Regulation of Actin Cytoskeleton
Differentiation Pathway
Hair Follicle Development: Organogenesis (Part 2 of 3)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
PIP3 activates AKT signaling
Integrated Pancreatic Cancer Pathway
Signaling by FGFR
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.